865449-19-0

Basic information

• Product Name: 2-bromo-4-(dibromomethyl)pyridine
• Synonyms: 2-bromo-4-(dibromomethyl)pyridine
• CAS NO: 865449-19-0
• Molecular Formula: C₆H₄Br₃N
• Molecular Weight: 330
• Mol File: 865449-19-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-bromo-4-(dibromomethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-4-(dibromomethyl)pyridine(865449-19-0)
• EPA Substance Registry System: 2-bromo-4-(dibromomethyl)pyridine(865449-19-0)

Safety Data

• Hazardous Substances Data: 865449-19-0(Hazardous Substances Data)

Upstream product

• 4926-28-7 2-Bromo-4-picoline 
• 695-34-1 2-Amino-4-methylpyridine 

Downstream Products

• 773121-98-5 (E)-3-(2-bromopyridin-4-yl)acrylic acid 
• 1261288-05-4 C₁₉H₁₄BrN₃ 
• 118289-17-1 2-bromopyridine-4-carboxaldehyde 

Relevant articles and documents

gem-dibromomethylarenes: A convenient substitute for noncommercial aldehydes in the Knoevenagel-Doebner reaction for the synthesis of α,β-unsaturated carboxylic acids

(Chemical Equation Presented) A facile synthesis of α,β- unsaturated carboxylic acids from gem-dibromomethylarenes is described. gem-Dibromomethylarenes are employed for the first time in the Knoevenagel-Doebner reaction as aldehyde equivalents for the efficient synthesis of α,β-unsaturated carboxylic acids.

The expedient access to bromo-pyridine carbaldehyde scaffolds using gem-dibromomethyl intermediates

A simple, efficient, and general two-step synthesis to bromo-pyridine carbaldehyde scaffolds is described. This direct route involves sequential reactions employing the dibromination of bromo-picolines followed by hydrolysis using an aqueous solution of calcium carbonate. Bromo-pyridine carbaldehyde scaffolds 1-7 were obtained in good overall yield. Bromo-dibromomethyl-pyridine intermediates have been isolated and characterized.