865449-87-2Relevant academic research and scientific papers
Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity
Judd, Andrew S.,Souers, Andrew J.,Wodka, Dariusz,Zhao, Gang,Mulhern, Mathew M.,Iyengar, Rajesh R.,Gao, Ju,Lynch, John K.,Freeman, Jennifer C.,Falls, H. Douglas,Brodjian, Sevan,Dayton, Brian D.,Reilly, Regina M.,Gintant, Gary,Limberis, James T.,Mikhail, Ann,Leitza, Sandra T.,Houseman, Kathryn A.,Diaz, Gilbert,Bush, Eugene N.,Shapiro, Robin,Knourek-Segel, Victoria,Hernandez, Lisa E.,Marsh, Kennan C.,Sham, Hing L.,Collins, Christine A.,Kym, Philip R.
, p. 2365 - 2371 (2008/02/01)
A series of potent 2-carboxychromone-based melanin-concentrating hormone receptor 1 (MCHr1) antagonists were synthesized and evaluated for hERG (human Ether-a-go-go Related Gene) channel affinity and functional blockade. Basic dialkylamine-terminated anal
Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
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Page/Page column 46, (2010/02/14)
The present invention is directed to compounds of formula (I), which antagonize of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.
