865451-79-2Relevant academic research and scientific papers
Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)- pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a clinical candidate
Anselm, Lilli,Banner, David W.,Benz, J?rg,Groebke Zbinden, Katrin,Himber, Jacques,Hilpert, Hans,Huber, Walter,Kuhn, Bernd,Mary, Jean-Luc,Otteneder, Michael B.,Panday, Narendra,Ricklin, Fabienne,Stahl, Martin,Thomi, Stefan,Haap, Wolfgang
scheme or table, p. 5313 - 5319 (2010/10/21)
A series of (3R,4R)-pyrrolidine-3,4-dicarboxylic acid amides was investigated with respect to their factor Xa inhibitory activity, selectivity, pharmacokinetic properties, and ex vivo antithrombotic activity. The clinical candidate from this series, R1663
NOVEL PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVES
-
Page/Page column 44, (2008/06/13)
The invention is concerned with novel pyrrolidine-3,4-dicarboxamide derivatives of Formula (I) ; wherein Rl to R9 and X are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These c
