865451-85-0

Usage

Uses

Used in Pharmaceutical Industry:
(3-fluorooxetan-3-yl)methanol is used as a chemical intermediate for the synthesis of pharmaceutical compounds due to its unique structure and functional groups. The fluorine atom can impart specific properties to the molecule, making it useful in various chemical reactions and synthesis processes. This can lead to the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
(3-fluorooxetan-3-yl)methanol is used as a building block for the creation of agrochemicals, such as pesticides and herbicides, due to its potential to enhance the activity and selectivity of these compounds. The unique structure and functional groups of (3-fluorooxetan-3-yl)methanol can contribute to the development of more effective and environmentally friendly agrochemicals.
Used in Chemical Reactions and Synthesis:
(3-fluorooxetan-3-yl)methanol is used as a reagent in various chemical reactions and synthesis processes due to its fluorinated nature and the presence of the oxetane ring. The fluorine atom can participate in reactions that may not be possible with other alcohol derivatives, while the oxetane ring can provide structural rigidity and stability to the molecule, making it suitable for specific applications in organic synthesis.
Further research and exploration of (3-fluorooxetan-3-yl)methanol may uncover additional potential uses and benefits in different fields, such as materials science, where its unique structure and properties could be harnessed for the development of new materials with specific characteristics.

Upstream product

• 1620017-27-7 tert-butyl[(3-fluorooxetan-3-yl)methoxy]diphenylsilane 
• 865451-84-9 3-benzyloxymethyl-3-fluorooxetane 

Downstream Products

• 865451-86-1 3-(bromomethyl)-3-fluorooxetane 

Relevant academic research and scientific papers

Method for preparing 3-fluorooxetane-3-methanol and intermediate of 3-fluorooxetane-3-methanol

The invention discloses a method for preparing 3-fluorooxetane-3-methanol and an intermediate of 3-fluorooxetane-3-methanol. The method comprises the following steps of: performing a cyclization reaction on a compound represented by a formula 5 and strong base in organic solvent so as to obtain a compound represented by a formula 6, wherein R1 is a methylsulfonyl group or a p-methylphenylsulfonylgroup or a p-trifluoromethylbenzenesulfonyl group or a trifluoromethylsulfonyl group; preforming a reaction on magnesium and the compound represented by the formula 6 in organic solvent so as to obtain a compound 7. The method has the advantages of being high in yield, simple to operate and simple in post-treatment, and is suitable for large-scale production.

HYDROXYL PURINE COMPOUNDS AND USE THEREOF

Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNFα inhibitors, in particular, the compounds as shown in formula (I), or tautomers or pharmaceutically acceptable salts thereof.

ANTIFIBROTIC EFFECTS OF OXETANYL SULFOXIDES

A compound, or a pharmaceutically acceptable salt thereof, having a structure of wherein Z is aryl or substituted aryl, heteroaryl, or substituted heteroaryl; X is —S—, —S(O)—, or S(O)2—; R20 and R21 are each independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, or halogenated alkyl; one of R22, R23, and R24 is —O— and the others of R22, R23 and R24 are independently —CH2—, or —C(R13)— wherein R13 is alkyl, alkenyl, alkynyl, trialkylsilyl group, or —(CH2)mOR15, wherein R15 is alkyl or an aryl and m is an integer in the range of 1 to 10; and R25 is H, alkyl, substituted alkyl, halogen, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, C1-C3 alkoxy, aryloxy, or —(CH2)qOR17, wherein R17 is alkyl an aryl and q is an integer in the range of 1 to 10.

A new and versatile synthesis of 3-substituted oxetan-3-yl methyl alcohols

We have developed a novel route for the efficient synthesis of pharmaceutically significant 3-substituted oxetan-3-yl methyl alcohols starting from readily available malonates. The synthesis harnesses the diversity of malonate chemistry and allows access to a range of oxetanes, which exemplifies the versatility of this procedure.

A new and versatile synthesis of 3-substituted oxetan-3-yl methyl alcohols

We have developed a novel route for the efficient synthesis of pharmaceutically significant 3-substituted oxetan-3-yl methyl alcohols starting from readily available malonates. The synthesis harnesses the diversity of malonate chemistry and allows access to a range of oxetanes, which exemplifies the versatility of this procedure.

NOVEL PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVES

The invention is concerned with novel pyrrolidine-3,4-dicarboxamide derivatives of Formula (I) ; wherein Rl to R9 and X are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These c