865451-85-0

Basic information

• Product Name: (3-fluorooxetan-3-yl)methanol
• Synonyms: (3-fluorooxetan-3-yl)methanol;3-Fluoro-3-oxetaneMethanol;3-Fluoro-3-oxetaneMethano...;3-Fluoro-3-(hydroxymethyl)oxetane (3-Fluorooxetan-3-yl)methanol
• CAS NO: 865451-85-0
• Molecular Formula: C4H7FO2
• Molecular Weight: 106.0955832
• Mol File: 865451-85-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 137.5±15.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 14.58±0.10(Predicted)
• CAS DataBase Reference: (3-fluorooxetan-3-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (3-fluorooxetan-3-yl)methanol(865451-85-0)
• EPA Substance Registry System: (3-fluorooxetan-3-yl)methanol(865451-85-0)

Safety Data

• Hazard Codes: T,N
• Statements: 22-36/37/38
• Safety Statements: 26-36/37
• TSCA: No
• Hazardous Substances Data: 865451-85-0(Hazardous Substances Data)

Usage

General Description

(3-fluorooxetan-3-yl)methanol is a chemical compound with the molecular formula C5H9FO2. It is a fluorinated alcohol derivative, containing a fluorine atom and a five-membered oxetane ring. (3-fluorooxetan-3-yl)methanol may have potential applications in the pharmaceutical or agrochemical industries due to its unique structure and functional groups. The fluorine atom can impart specific properties to the molecule, making it useful in various chemical reactions and synthesis. Additionally, the oxetane ring can provide structural rigidity and stability to the molecule, which may be beneficial for certain applications. Further research and exploration of (3-fluorooxetan-3-yl)methanol may uncover its potential uses and benefits in different fields.

Upstream product

• 1620017-27-7 tert-butyl[(3-fluorooxetan-3-yl)methoxy]diphenylsilane 
• 865451-84-9 3-benzyloxymethyl-3-fluorooxetane 

Downstream Products

• 865451-86-1 3-(bromomethyl)-3-fluorooxetane 

Relevant articles and documents

Method for preparing 3-fluorooxetane-3-methanol and intermediate of 3-fluorooxetane-3-methanol

The invention discloses a method for preparing 3-fluorooxetane-3-methanol and an intermediate of 3-fluorooxetane-3-methanol. The method comprises the following steps of: performing a cyclization reaction on a compound represented by a formula 5 and strong base in organic solvent so as to obtain a compound represented by a formula 6, wherein R1 is a methylsulfonyl group or a p-methylphenylsulfonylgroup or a p-trifluoromethylbenzenesulfonyl group or a trifluoromethylsulfonyl group; preforming a reaction on magnesium and the compound represented by the formula 6 in organic solvent so as to obtain a compound 7. The method has the advantages of being high in yield, simple to operate and simple in post-treatment, and is suitable for large-scale production.

ANTIFIBROTIC EFFECTS OF OXETANYL SULFOXIDES

A compound, or a pharmaceutically acceptable salt thereof, having a structure of wherein Z is aryl or substituted aryl, heteroaryl, or substituted heteroaryl; X is —S—, —S(O)—, or S(O)2—; R20 and R21 are each independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, or halogenated alkyl; one of R22, R23, and R24 is —O— and the others of R22, R23 and R24 are independently —CH2—, or —C(R13)— wherein R13 is alkyl, alkenyl, alkynyl, trialkylsilyl group, or —(CH2)mOR15, wherein R15 is alkyl or an aryl and m is an integer in the range of 1 to 10; and R25 is H, alkyl, substituted alkyl, halogen, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, C1-C3 alkoxy, aryloxy, or —(CH2)qOR17, wherein R17 is alkyl an aryl and q is an integer in the range of 1 to 10.

A new and versatile synthesis of 3-substituted oxetan-3-yl methyl alcohols

We have developed a novel route for the efficient synthesis of pharmaceutically significant 3-substituted oxetan-3-yl methyl alcohols starting from readily available malonates. The synthesis harnesses the diversity of malonate chemistry and allows access to a range of oxetanes, which exemplifies the versatility of this procedure.