86549-28-2

Basic information

• Product Name: 4-((TriMethylsilyl)ethynyl)isoquinoline
• Synonyms: 4-((TriMethylsilyl)ethynyl)isoquinoline
• CAS NO: 86549-28-2
• Molecular Formula: C₁₄H₁₅NSi
• Molecular Weight: 225.3611
• Mol File: 86549-28-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-((TriMethylsilyl)ethynyl)isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((TriMethylsilyl)ethynyl)isoquinoline(86549-28-2)
• EPA Substance Registry System: 4-((TriMethylsilyl)ethynyl)isoquinoline(86549-28-2)

Safety Data

• Hazardous Substances Data: 86549-28-2(Hazardous Substances Data)

Usage

General Description

"4-((Trimethylsilyl)ethynyl)isoquinoline" is a chemical compound that belongs to the class of isoquinoline derivatives. It is a derivative of isoquinoline with a trimethylsilyl group attached to the ethynyl position. 4-((TriMethylsilyl)ethynyl)isoquinoline is commonly used in organic synthesis and medicinal chemistry as a building block for the preparation of complex molecules. It possesses unique properties due to the presence of the trimethylsilyl group, making it an important intermediate in the development of pharmaceuticals and other biologically active compounds. Its structure and reactivity make it a valuable tool in the field of chemical research and drug discovery.

Upstream product

• 1532-97-4 4-bromoisoquinoline 
• 7681-65-4 copper(I) iodide 
• 1066-54-2 trimethylsilylacetylene 
• 55270-33-2 4-iodo-isoquinoline 

Relevant articles and documents

Synthesis and in vitro biological evaluation of (iso)quinoline-1,2,3-triazole derivatives as anticancer agents

Two series of triazole derivatives were designed and synthesized as potential anticancer agents. A series of eighteen novel 1,2,3-triazole derivatives were synthesized through copper catalyzed click reaction. The compounds were evaluated for their cytotoxicity activity against HepG2, HeLa cell and HEK293 cell lines using MTT assay. The results showed that compounds 10 and 11 were the most potent compounds against HepG2 cell with IC50 values 9.6 and 13.3?μM, respectively. Additionally, the compounds 10 and 11 were the most potent compounds against HeLa cell with IC50 values 5.7 and 5.8?μM, respectively. The results of tubulin polymerization assay demonstrated that lead compound 2 and compound 10 could inhibit in vitro tubulin polymerization. In addition, a mechanism study displayed that 10 blocked cell cycle arrest at G2/M phase. Furthermore, a molecular docking study demonstrated that 10 can bind to the colchicine site of tubulin and form hydrogen bonds in the active site of β-tubulin. In summary, our study recommends a promising isoquinoline-triazole scaffold for further development as more efficient microtubule polymerization inhibitors in the field of cancer treatment. Graphical abstract: [Figure not available: see fulltext.]

Aryl Nitriles from Alkynes Using tert -Butyl Nitrite: Metal-Free Approach to C≡C Bond Cleavage

Alkyne C≡C bond breaking, outside of alkyne metathesis, remains an underdeveloped area in reaction discovery. Recently, nitrogenation has been reported to allow nitrile formation from alkynes. A new protocol for the metal-free C≡C bond cleavage of terminal alkynes to produce nitriles is reported. This method provides an opportunity to synthesize a vast range of nitriles containing aryl, heteroaryl, and natural product derivatives (38 examples). In addition, the potential of tBuONO to act as a powerful nitrogenating agent for terminal aryl alkynes is demonstrated. (Figure Presented).

CONDENSED-CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DIODE COMPRISING THE SAME

Embodiments of the present invention are directed to a condensed-cyclic compound represented by Formula 1, and to an organic light-emitting diode including the same.