86560-40-9Relevant academic research and scientific papers
Ytterbium-Catalyzed Intramolecular [3 + 2] Cycloaddition based on Furan Dearomatization to Construct Fused Triazoles
Xu, Xiaoming,Zhong, Ying,Xing, Qingzhao,Gao, Ziwei,Gou, Jing,Yu, Binxun
, p. 5176 - 5181 (2020/07/14)
The 1,2,3-triazole-containing polycyclic architecture widely exists in a broad spectrum of synthetic bioactive molecules, and the development of expeditious methods to synthesize these skeletons remains a challenging task. In this work, the catalytic cyclization of biomass-derived 2-furylcarbinols with an azide to form fused triazoles is described. This approach takes advantage of a single catalyst Yb(OTf)3 and operates via a furfuryl-cation-induced intramolecular [3 + 2] cycloaddition/furan ring-opening cascade.
A raney-cobalt-mediated tandem reductive cyclization route to the 1,5-methanoazocino[4,3-b]indole framework of the uleine and strychnos alkaloids
Reekie, Tristan A.,Banwell, Martin G.,Willis, Anthony C.
, p. 10773 - 10781 (2013/02/22)
The readily accessible enones 8, 17, and 18 undergo 2-fold reductive cyclization reactions upon exposure to hydrogen in the presence of Raney-cobalt and thereby afford compounds 11 (72%), 19 (47%), and 20 (84%), respectively. These products embody the ABC
Expedient synthesis of 3-substituted cycloalkanones via a Pd-catalyzed decarboxylative protonation protocol
Kim, Se Hee,Kim, Eun Sun,Kim, Taek Hyeon,Kim, Jae Nyoung
experimental part, p. 6256 - 6260 (2010/01/11)
We developed an efficient method for the introduction of -CH2EWG moiety at the β-position of 2-cycloalken-1-ones via a Pd-catalyzed decarboxylative protonation protocol.
Tandem cationic aza-cope rearrangement-Mannich cyclization approach to the core structure of FR901483 via a Bridgehead iminium ion.
Brummond,Lu
, p. 1347 - 1349 (2007/10/03)
[reaction in text] An approach to the potent immunosuppressant FR901483 is described. This route utilizes a tandem cationic aza-Cope rearrangement-Mannich cyclization to generate the core structure of this compound. In addition, this is the first demonstr
CONJUGATE ADDITION REACTION OF TRIMETHYLSILYLACETONITRILE WITH Α,Β-UNSATURATED CARBONYL COMPOUNDS. SYNTHETIC STUDIES TOWARD SESBANIMIDE
Tomioka, Kiyoshi,Koga, Kenji
, p. 1599 - 1600 (2007/10/02)
Lithiated trimethylsilylacetonitrile was allowed to react with some α,β-unsaturated carbonyl compounds to give the corresponding conjugate addition products.
A METHOD OF CONJUGATE ADDITION OF ACETONITRILE AND PROPIONITRILE TO CYCLENONES: SYNTHESIS OF 3 CYANOMETHYL AND CYANO-1' ETHYLCYCLANONES
Hatzigrigoriou, E.,Wartski, L.
, p. 319 - 326 (2007/10/02)
Conjugate addition on α-unsaturated carbonyl compounds is an important method for carbon-carbon bond making.This can be easily realized using lithiated stabilized carbanions such as -Li+ (1).However only carbonyl attack is observed using metallated acetonitriles -M+ in THF whatever the cation (Li+, Na+, K+) is (1a).
