865879-52-3Relevant academic research and scientific papers
[Hydroxy(aryl)methylene]diphosphonic acids, a class of drugs in bone pathology treatments, crystallize as head-to-head dimers
Lecouvey, Marc,Barbey, Carole,Navaza, Alda,Neuman, Alain,Prange, Thierry
, p. o521-o524 (2002)
Two [hydroxy(aryl)methylene]diphosphonic acids have been crystallized as dimers. The first compound, [hydroxy(phenyl)methylene]diphosphonic acid monohydrate, C7H10O7P2·H2O, crystallizes in the non-cen
Synthesis of 1-hydroxymethylene-1,1-bis(phosphonic acids) from acid anhydrides: Preparation of a new cyclic 1-acyloxymethylene-1,1-bis(phosphonic acid)
Guenin, Erwann,Degache, Estelle,Liquier, Jean,Lecouvey, Marc
, p. 2983 - 2987 (2007/10/03)
In continuing with our work to find new pathways to bis(phosphonate) structures we report on their synthesis from tris(trimethylsilyl) phosphite and acid anhydride. This new synthesis allows a direct access to a 1-hydroxymethylene-1,1-bis(phosphonic acid) functionalised by a carboxylic function on the side chain. Moreover, we describe the formation of an original cyclic bis(phosphonate) obtained from phthalic anhydride. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
