86601-30-1Relevant academic research and scientific papers
Cu(OAc)2 mediated mild synthesis of 2-aminobenzimidazoles and 2-aminobenzoxazoles
Gan, LinLing,Gan, Zongjie,Han, Lei,Hu, Xiangnan,Li, Wei,Wu, Yue,Yu, Yu,Zheng, Jiecheng,Zhu, Dali
, (2022/05/13)
An efficient and facile synthesis for 2-aminobenzimidazoles and 2-aminobenzoxazoles has been reported. Thioureas prepared from the reaction of o-phenylenediamines or 2-aminophenols and isothiocyanate derivatives, underwent desulfurization reaction smoothly under mild conditions in the presence of Cu(OAc)2, and afforded a variety of N-heterocyclic compounds in moderate to good yields.
De novodesign and synthesis of dipyridopurinone derivatives as visible-light photocatalysts in productive guanylation reactions
Gao, Wenjing,Ma, Nana,Wan, Yameng,Wu, Hao,Zhang, Guisheng,Zhang, Zhiguo,Zhao, Jie
, p. 15988 - 15997 (2021/12/30)
Described here is thede novodesign and synthesis of a series of 6H-dipyrido[1,2-e:2′,1′-i]purin-6-ones (DPs) as a new class of visible-light photoredox catalysts (PCs). The synthesizedDP1-5showed theirλAbs(max)values in 433-477 nm, excited state redox potentials in 1.15-0.69 eV and ?1.41 to ?1.77 eV (vs.SCE), respectively. As a representative,DP4enables the productive guanylation of various amines, including 1°, 2°, and 3°-alkyl primary amines, secondary amines, aryl and heteroaryl amines, amino-nitrile, amino acids and peptides as well as propynylamines and α-amino esters giving diversities in biologically important guanidines and cyclic guanidines. The photocatalytic efficacy ofDP4in the guanylation overmatched commonly used Ir and Ru polypyridyl complexes, and some organic PCs. Other salient merits of this method include broad substrate scope and functional group tolerance, gram-scale synthesis, and versatile late-stage derivatizations that led to a derivative81exhibiting 60-fold better anticancer activity against Ramos cells with the IC50of 0.086 μM than that of clinical drug ibrutinib (5.1 μM).
