86601-74-3

Upstream product

• 52479-65-9 1-(2-methylaminobenzoyl)hydrazine 
• 93595-30-3 1-o-aminobenzoyl-4,4-dimethylsemicarbazide 
• 10328-92-4 N-Methylisatoic anhydride 
• 93595-56-3 5-(2-methylaminophenyl)-1,3,4-oxadiazole-2(3H)-one 
• 74-88-4 methyl iodide 
• 86601-73-2 5-(2-aminophenyl)-1,3,4-oxadiazol-2(3H)-one 

Relevant academic research and scientific papers

The Preparation of 5-(2-Aminophenyl)-1,3,4-oxadiazole-2(3H)-one and Its Rearrangement to 3-Amino-2,4(1H,3H)-quinazolinedione

When anthranilic acid hydrazide is reacted with 1,1'-carbonyldiimidazole in THF 5-(2-aminophenyl)-1,3,4-oxadiazole-2(3H)-one (4) is formed.It can also be prepared from 1-o-aminobenzoyl-4,4-dimethylsemicarbazide which eliminates methylamine when boiled with DMF.On heating the 5-(2-aminophenyl)-1,3,4-oxadiazole above its melting point it rearranges to 3-amino-2,4(1H,3H)-quinazolinedione (5). - Keywords: 3,4-Dihydro-1H-1,3,4-benzotriazepine-2,5-dione; Oxadiazoles

REINVESTIGATION OF A RECENT 1,3,4-BENZOTRIAZEPINE SYNTHESIS, FORMATION OF 1,3,4-OXADIAZOLES

It was shown by spectroscopic and synthetic methods that the reaction of anthranilic acid hydrazides with 1,1'-carbonylbisimidazole (CO/Im/2) afforded, in contrast with earlier literature data, no 1,3,4-benzotriazepines or quinazolines but 1,3,4-oxadiazole derivatives.