86601-73-2

Upstream product

• 606-26-8 o-nitrobenzohydrazide 
• 118-48-9 isatoic anhydride 
• 134-20-3 2-carbomethoxyaniline 
• 118-92-3 anthranilic acid 
• 530-62-1 1,1'-carbonyldiimidazole 
• 1904-58-1 anthranilic acid hydrazide 
• 93595-33-6 C₁₂H₁₈N₄O₂ 
• 93595-29-0 1-o-aminobenzoyl-4,4-dimethylsemicarbazide 
• 83725-79-5 5-(2-nitrophenyl)-1,3,4-oxadiazole-2(3H)-one 

Downstream Products

• 86601-74-3 2-methyl-5-(2-methylaminophenyl)-1,3,4-oxadiazole-2(3H)-one 
• 1086462-63-6 C₂₂H₁₄IN₅O₂ 
• 1086462-60-3 C₂₂H₁₅N₅O₂ 
• 1086462-62-5 C₂₂H₁₄ClN₅O₂ 
• 1086462-61-4 C₂₂H₁₄BrN₅O₂ 

Relevant academic research and scientific papers

Substituted phenyl derivatives, their preparation and use

The present invention discloses compounds having the formula wherein the substituents are defined in the application. The compounds are useful as chloride channel blockers.

Synthesis and Pharmacological Evaluation of Fenamate Analogues: 1,3,4-Oxadiazol-2-ones and 1,3,4-Oxadiazole-2-thiones

A series of fenamate pyridyl or quinolinyl analogues of 1,3,4-oxadiazol-2-ones 5a-d and 6a-r, and 1,3,4-oxadiazole-2-thiones 5e-g and 6s-v, respectively, have been synthesized and evaluated for their analgesic (hot-plate), antiinflammatory (carrageenin induced rat's paw edema) and ulcerogenic effects as well as plasma prostaglandin E2 (PGE 2) level. The highest analgesic activity was achieved with compound 5a (0.5, 0.6, 0.7 mmol/kg b.wt.) in respect with mefenamic acid (0.4 mmol/kg b.wt.). Compounds 6h, 61 and 5g showed 93, 88 and 84% inhibition, respectively on the carrageenan-induced rat's paw edema at dose level of 0.1mmol/kg, b.wt, compared with 58% inhibition of mefenamic acid (0.2mmol/kg b.wt.). Moreover, the highest inhibitory activity on plasma PGE2 level was displayed also with 6h, 61 and 5g (71, 70, 68.5% respectively, 0.1mmol/kg b.wt.) compared with indomethacin (60%, 0.01 mmol/kg b.wt.) as a reference drug. In addition 6i, 6k, 6p, 6r, 6t and 6v were devoid of any ulcerogenicity.

Substituted phenyl derivatives, their preparation and use

The present invention discloses compounds having the formula wherein the substituents are defined in the application. The compounds are useful as chloride channel blockers.

Substituted phenyl derivatives, their preparation and use

A compound having the formula (I) or a pharmaceutically acceptable salt thereof where the variables are defined in the specification are useful in the treatment of sickle-cell anemia.

The Preparation of 5-(2-Aminophenyl)-1,3,4-oxadiazole-2(3H)-one and Its Rearrangement to 3-Amino-2,4(1H,3H)-quinazolinedione

When anthranilic acid hydrazide is reacted with 1,1'-carbonyldiimidazole in THF 5-(2-aminophenyl)-1,3,4-oxadiazole-2(3H)-one (4) is formed.It can also be prepared from 1-o-aminobenzoyl-4,4-dimethylsemicarbazide which eliminates methylamine when boiled with DMF.On heating the 5-(2-aminophenyl)-1,3,4-oxadiazole above its melting point it rearranges to 3-amino-2,4(1H,3H)-quinazolinedione (5). - Keywords: 3,4-Dihydro-1H-1,3,4-benzotriazepine-2,5-dione; Oxadiazoles

REINVESTIGATION OF A RECENT 1,3,4-BENZOTRIAZEPINE SYNTHESIS, FORMATION OF 1,3,4-OXADIAZOLES

It was shown by spectroscopic and synthetic methods that the reaction of anthranilic acid hydrazides with 1,1'-carbonylbisimidazole (CO/Im/2) afforded, in contrast with earlier literature data, no 1,3,4-benzotriazepines or quinazolines but 1,3,4-oxadiazole derivatives.