86602-75-7Relevant academic research and scientific papers
Magnesium perchlorate as a new and highly efficient catalyst for the synthesis of 2,3-dihydro-1,5-benzothiazepines
Khatik, Gopal L.,Kumar, Raj,Chakraborti, Asit K.
, p. 541 - 546 (2007)
Commercially available magnesium perchlorate has been found to be a highly efficient catalyst for the reaction of 1,3-diarylprop-2-enones with 2-aminothiophenol leading to the synthesis of 2,3-dihydro-1,5-benzothiazepines in high yields and in short times. Georg Thieme Verlag Stuttgart.
Synthesis, characterization, in vitro cholinesterase and hRBCs hemolysis assay and computational evaluation of novel 2,3,4,5-tetrahydrobenzothiazepine appended α-aminophosphonates
Shaikh, Sarfaraz,Dhavan, Pratik,Uparkar, Jasmin,Singh, Pinky,Vaidya,Jadhav,Ramana
, (2021/10/12)
A series of novel 2,3,4,5-tetrahydrobenzothiazepine appended α-aminophosphonate derivatives were synthesized by subjecting 2,3-dihydrobenzothiazepine to Pudovik reaction using diethyl phosphite. Tested derivatives exhibited better AChE inhibition (0.86–12
Microwave assisted synthesis of 1,5-benzothiazepines using greener reaction medium
Kotalwar, Sanjay S.,Kale, Amol D.,Kohire, Ram B.,Jagrut, Vasant B.
, p. 993 - 996 (2019/04/05)
An efficient and eco-friendly synthesis of 1,5-benzothiazepines has been developed by the reaction of various 2-propen-1-ones with 2-aminothiophenol using microwave irradiation in greener reaction medium, glycerol. The clean reaction conditions, shorter r
An improved procedure for the synthesis of 1,5-benzothiazepines using ceric ammonium nitrate (CAN)
Chate, Asha V.,Joshi, Ratnadeep S.,Mandhane, Priyanka G.,Gill, Charansingh H.
experimental part, p. 776 - 780 (2012/01/03)
A mild and efficient procedure for the synthesis of various 1,5-benzothiazepines were developed. This method provides an easy access for preparation of 1,5-benzothiazepine derivatives in the presence of 10 mol% catalyst of CAN under ultrasonic irradiation. This method provided clean conversion, mild reaction condition, no use of toxic solvent and shorter reaction time compared to other reported method. Copyright
'On water' synthesis of 2,4-diaryl-2,3-dihydro-1,5-benzothiazepines catalysed by sodium dodecyl sulfate (SDS)
Sharma, Gaurav,Kumar, Raj,Chakraborti, Asit K.
, p. 4269 - 4271 (2008/09/21)
An efficient synthesis of 1,3-diaryl-2,3-dihydro-1,5-benzothiazepines has been developed by the reaction of various 1,3-diaryl-2-propenones with 2-aminothiophenol in water under neutral conditions catalysed by SDS. Excellent chemoselectivity was observed for substrates possessing halogen atoms or nitro/alkoxy/thioalkyl groups which did not undergo competitive aromatic nucleophilic substitution of the halogen atoms or the nitro group, reduction of the nitro or the α,β-unsaturated carbonyl group, or dealkylation of the alkoxy/thioalkoxy groups.
