86602-77-9Relevant academic research and scientific papers
A novel 1,5-benzoheteroazepine synthesis via a one-pot coupling - Isomerization - Cyclocondensation sequence
Braun, Roland U.,Zeitler, Kirsten,Mueller, Thomas J. J.
, p. 4181 - 4184 (2000)
(equation presented) Ar1 = electron deficient (hetero)aryl Ar2 = aryl X = NH, O, S 2,4-Di(hetero)aryl substituted 2,3-dihydro 1,5-benzoheteroazepines (hetero = NH, O, S) can be readily sythesized in a one-pot process initiated by a coupling-isomerization sequence of an electron poor (hetero)aryl halide and a terminal propargyl alcohol subsequently followed by a cyclocondensation with 2-amino, 2-hydroxy, or 2-mercapto anilines. In addition, the structures were established unambiguously by an X-ray structure analysis of 7a.
One-pot syntheses of dihydro benzo[b][1,4]thiazepines and -diazepines via coupling-isomerization-cyclocondensation sequences
Braun, Roland U.,Müller, Thomas J.J.
, p. 9463 - 9469 (2007/10/03)
2,4-Di(hetero)aryl substituted 2,3-dihydro benzo[b][1,4]heteroazepines 7 and 9 (hetero=S, NH) can be readily synthesized in a one-pot process initiated by a coupling-isomerization sequence of an electron poor (hetero)aryl halide 4 and a terminal propargyl alcohol 5 subsequently followed by a cyclocondensation with 2-mercapto or 2-amino anilines 6 or 8, respectively. In addition, the structures were established unambiguously by an X-ray structure analysis of 9b. Graphical abstract.
