86604-40-2Relevant academic research and scientific papers
Synthesis of thieno[2,3-b]quinolinone derivatives
Han, Guang-Fan,Wang, Ming,Chen, Li-Zhuang,Hu, Xiao-Lei
, p. 909 - 912 (2012/10/29)
The Knoevenagel reactions of malononitrile with acetophenone or 4-substituted acetophenons were carried to give the corresponding 2-(1-aryle thylidene)malononitriles, which was further cyclized with sulfur using NaHCO3 as catalysts to generate
Synthesis of substituted amino-cycloalkyl[b]thieno-[3,2-e]pyridines
Seek, Pierre,Thomae, David,Kirsch, Gilbert
, p. 853 - 857 (2008/09/21)
(Chemical Equation Presented) An efficient two respectively three steps procedure for the synthesis of cycloalkyl[b]thieno[3,2-e]-pyridine amines was developed and in general good to very good yields were obtained.
New conditions for the synthesis of thiophenes via the Knoevenagel/Gewald reaction sequence. Application to the synthesis of a multitargeted kinase inhibitor
Barnes, David M.,Haight, Anthony R.,Hameury, Thomas,McLaughlin, Maureen A.,Mei, Jianzhang,Tedrow, Jason S.,Riva Toma, Joan Dalla
, p. 11311 - 11319 (2007/10/03)
Novel conditions have been developed for the preparation of substituted 2-aminothiophenes employing the Knoevenagel condensation followed by the Gewald reaction. The benefits of these conditions are their mildness, and the ease of product isolation. Thus,
Synthesis of polyfunctionally substituted thiophene, thieno[2,3-b]pyridine and thieno[2,3-d]pyrimidine derivatives
Wardakhan, Wagnat W.,Shams, Hoda Z.,Moustafa, Hosam E.
, p. 1815 - 1827 (2007/10/03)
The thiophne derivatives 4a-c were prepared according to the Gewald procedure. Their reactivity towards a variety of chemical reagents was studied to give thienopyridines and pyrimidines. Biological investigations were carried on the newly synthesized pro
