2972-85-2

Usage

Uses

Used in Pharmaceutical Research:
[1-(4-methoxyphenyl)ethylidene]propanedinitrile is used as a research compound for its potential antitumor properties, making it a valuable asset in cancer research. Its unique structure and pharmacological activities contribute to the development of novel therapeutic strategies against various types of cancer.
Used in Organic Synthesis:
As an intermediate, [1-(4-methoxyphenyl)ethylidene]propanedinitrile is employed in the synthesis of various other compounds, showcasing its versatility and importance in the field of organic chemistry. Its ability to be modified and incorporated into different molecular structures highlights its utility in creating new and potentially beneficial chemical entities.
Used in Chemical Intermediates Industry:
[1-(4-methoxyphenyl)ethylidene]propanedinitrile is used as a key intermediate in the production of various pharmaceuticals and other chemical products. Its role in this industry is crucial, as it enables the creation of a wide range of compounds with diverse applications, from medical treatments to industrial processes.

Upstream product

• 18394-32-6 (1-Chlorethyliden)propandinitril 
• 100-66-3 methoxybenzene 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 109-77-3 malononitrile 

Downstream Products

• 10432-50-5 3-(4-Methoxy-phenyl)-3-methyl-cyclopropane-1,1,2,2-tetracarbonitrile 
• 128342-40-5 6-(furan-2-yl)-4-(4-methoxyphenyl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 128342-41-6 4-(4-methoxyphenyl)-6-(thiophen-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 89507-36-8 [6-Amino-5-cyano-4-(4-methoxy-phenyl)-thiopyran-(2E)-ylidene]-cyano-acetic acid ethyl ester 
• 79111-73-2 4-(4-Methoxyphenyl)-2-methylthio-penta-1,4-dien-1,1,5,5-tetracarbonitril 
• 128342-38-1 3-cyano-4-(4-methoxyphenyl)-6-(4-methylphenyl)-pyridin-2(1H)-thione 
• 128342-37-0 6-(4-Chloro-phenyl)-4-(4-methoxy-phenyl)-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 
• 128342-39-2 4,6-Bis-(4-methoxy-phenyl)-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 
• 84488-33-5 2-{1-(4-Methoxy-phenyl)-2-[5-(4-methoxy-phenyl)-[1,2]dithiol-(3Z)-ylidene]-ethylidene}-malononitrile 
• 84488-34-6 5-Imino-2,7-bis-(4-methoxy-phenyl)-5H-thieno[3,2-b]thiopyran-6-carbonitrile 
• 86641-63-6 2-{(4-Methoxy-phenyl)-[5-(4-methoxy-phenyl)-3-methylsulfanyl-thiophen-2-yl]-methylene}-malononitrile 
• 89507-33-5 [6-Amino-5-cyano-4-(4-methoxy-phenyl)-thiopyran-(2E)-ylidene]-cyano-acetic acid methyl ester 
• 127844-78-4 <2-Phenylazo-2-phenylhydrazono-1-(4-methoxyphenyl)ethylidene>malononitrile 
• 89805-57-2 2-amino-4-(4-methoxyphenyl)-6-(methylthio)nicotinonitrile 

Relevant academic research and scientific papers

A [5 + 1] annulation strategy for the synthesis of multifunctional biaryls and: P -teraryls from 1,6-Michael acceptor ketene dithioacetals

A new type of ketene dithioacetal, 2-(3,3-bis-methylsulfanyl-1-arylallylidene)malononitriles containing 1,4 and 1,6-Michael acceptors, were synthesized to study their reactivity for the synthesis of a new molecular entity. We report a [5 + 1] annulation s

Transition metal free synthesis of multifunctional thiomethylated-benzenes from aryl/heteroaryl/cyclopropyl methyl ketones

A base-promoted strategic synthesis of various functionalized thiomethylated-benzenes has been established from aryl/heteroaryl/cyclopropyl methyl ketone. We can directly access the thiomethylated-benzene nucleus embedded with diverse functional group by

"on Water" Direct Catalytic Vinylogous Aldol Reaction of Silyl Glyoxylates

The unique reactivity of water in the direct catalytic vinylogous aldol reaction of silyl glyoxylates is reported. With the hydrogen-bonding networks from water, the unfavorable homogeneous reactions in organic solvents were severely suppressed, and the "

Chemoselective synthesis of m-teraryls through ring transformation of 2 H-pyran-2-ones by 2-(1-arylethylidene)-malononitriles

We have developed a simple, efficient and chemoselective approach for the synthesis of m-teraryls by the reaction of 6-aryl-2-oxo-4-(sec.amino)-2H-pyran-3-carbonitriles and 2-(1-arylethylidene)malononitriles under basic conditions. We used 6-aryl-2-oxo-4-

Syntheses of donor-acceptor-functionalized dihydroazulenes

The dihydroazulene (DHA)/vinylheptafulvene (VHF) photo/thermoswitch has been of interest for use in molecular electronics and advanced materials. The switching between the two isomers has previously been found to depend strongly on the presence of donor a

Phosphine-catalyzed domino reaction: A novel sequential [2+3] and [3+2] annulation reaction of γ-substituent allenoates to construct bicyclic[3, 3, 0]octene derivatives

We have successfully developed a novel and efficient phosphine-catalyzed sequential [2+3] and [3+2] annulation reaction of γ-substituent allenoates to construct bicyclic[3, 3, 0]octene derivatives. The protocol uses readily available γ-substituent allenoa

A catalytic asymmetric hetero-Diels-Alder reaction of olefinic azlactones and isatins: Facile access to chiral spirooxindole dihydropyranones

A catalytic asymmetric hetero-Diels-Alder (HDA) reaction has been achieved through hydrogen-bond directed γ-addition of olefinic azlactones to isatins. This methodology provides an efficient access to spirooxindole dihydropyranones in moderate to good yie

Solventless convenient synthesis of new cyano-2-aminopyridine derivatives from enaminonitriles

A synthesis of novel 4-substituted-3-cyano-2-aminopyridines using enaminonitriles and various primary amines was established under microwave irradiation and solvent-free conditions. Structures of the new compounds were characterized by IR, MS, 1/sup

[5C + 1N] Annulation of 2,4-pentadienenitriles with hydroxylamine: A synthetic route to multi-substituted 2-aminopyridines

A facile and efficient synthetic route to multi-substituted 2-aminopyridines has been developed via a formal [5C + 1N] annulation of readily available 2,4-pentadienenitriles with hydroxylamine (NH2OH) under very mild conditions, which involves

Synthesis of thieno[2,3-b]quinolinone derivatives

The Knoevenagel reactions of malononitrile with acetophenone or 4-substituted acetophenons were carried to give the corresponding 2-(1-aryle thylidene)malononitriles, which was further cyclized with sulfur using NaHCO3 as catalysts to generate