86605-94-9Relevant academic research and scientific papers
Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11β-hydroxysteroid dehydrogenase type 1 inhibitors: Reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model
Fotsch, Christopher,Bartberger, Michael D.,Bercot, Eric A.,Chen, Michelle,Cupples, Rod,Emery, Maury,Fretland, Jenne,Guram, Anil,Hale, Clarence,Han, Nianhe,Hickman, Dean,Hungate, Randall W.,Hayashi, Michael,Komorowski, Renee,Liu, Qingyian,Matsumoto, Guy,St. Jean Jr., David J.,Ursu, Stefania,Véniant, Murielle,Xu, Guifen,Ye, Qiuping,Yuan, Chester,Zhang, Jiandong,Zhang, Xiping,Tu, Hua,Wang, Minghan
experimental part, p. 7953 - 7967 (2009/12/07)
A series of compounds containing the 2-amino-1,3-thiazol-4(5H)-one core were found to be potent inhibitors of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). One of our lead compounds from this series activated the human nuclear xenobiotic
