866050-41-1

Upstream product

• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 40401-39-6 1-(4-chlorophenyl)-3-methyl-1H-pyrazol-5-amine 
• 956574-60-0 2-{[2-(4-chloro-phenyl)-5-methyl-2H-pyrazol-3-ylamino]-methylene}-malonic acid diethyl ester 

Downstream Products

• 1025823-79-3 4-chloro-1-(4-chloro-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride 
• 1027516-07-9 4-chloro-1-(4-chloro-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 

Relevant academic research and scientific papers

Discovery of new orally active phosphodiesterase (PDE4) inhibitors

A series of 4-anilinopyrazolopyridine derivatives were synthesized and biologically evaluated as inhibitors of phosphodiesterase (PDE4). Chemical modification of 3, a structurally new chemical lead that was found in our in-house library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chemical lead 5 are presented. Structure-activity relationship data, pharmacological evaluation, and the subtype selectivity study are also presented.