866087-80-1Relevant articles and documents
Development of an alternative process for the manufacture of a key starting material for cefovecin sodium
Norris, Timothy,Nagakura, Isao,Morita, Hiromasa,McLachlan, Grant,Desneves, Joe
, p. 742 - 746 (2007)
A process has been developed for the use of trimethylphosphite for the formation of the six-membered 3,6-dihydro-2H-[1,3]-thiazine ring in the cephem architecture by an intramolecular Horner-Emmons-Wadsworth condensation. The process is a suitable alternative to the traditional Wittig process, which uses trimethylphosphine. The process developed is a highly telescoped reaction pathway consisting of at least six known reaction intermediates that was scaled for production use to produce 2.
PROCESS FOR PREPARING CEPHALOSPORIN INTERMEDIATES USING α-IODO-1-AZETIDINEACETIC ACID ESTERS AND TRIALKYLPHOSPHITES
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Page/Page column 18-19, (2010/02/14)
This invention relates a process for preparing a compound of formula (I), wherein R1 is para-nitrobenzyl or allyl; X is halo; as well as its isomers.