866102-74-1Relevant academic research and scientific papers
1,n-diamines. Part 2: Synthesis of acyclic and heterocyclic N-arylputrescine derivatives
Díaz, Jimena E.,Bisceglia, Juan á.,Mollo, Ma. Cruz,Orelli, Liliana R.
, p. 1895 - 1897 (2011/04/25)
In the present Letter we report the use of N-arylputrescines as synthetic intermediates for the preparation of N-acyl-N′-aryltetramethylenediamines 3 and related seven-membered heterocyclic amidines 4. Compounds 1 were synthesized by Cs2CO
An efficient synthesis of N-arylputrescines and cadaverines
Link, Natalia P.,Díaz, Jimena E.,Orelli, Liliana R.
experimental part, p. 751 - 754 (2009/07/18)
We present a two-step, general synthesis of N-aryl-putrescines and cadaverines, by cesium carbonate mediated alkylation of anilines with ω-chloronitriles and subsequent reduction. The cesium-mediated alkylation shows remarkable selectivity towards the mon
Modifications to the tetracaine scaffold produce cyclic nucleotide-gated channel blockers with widely varying efficacies
Strassmaier, Timothy,Uma, Ramalinga,Ghatpande, Ambarish S.,Bandyopadhyay, Tapasree,Schaffer, Michelle,Witte, John,McDougal, Patrick G.,Brown, R. Lane,Karpen, Jeffrey W.
, p. 5805 - 5812 (2007/10/03)
Five new tetracaine analogues were synthesized and evaluated for potency of blockade of cyclic nucleotide-gated channels relative to a multiply charged tetracaine analogue described previously (4). Increased positive charge at the tertiary amine end of tetracaine results in higher potency and voltage dependence of block. Modifications that reduce the hydrophobic character at the butyl tail are deleterious to block. The tetracaine analogues described here have apparent affinities for CNGA1 channels that vary over nearly 8 orders of magnitude.
