866108-77-2 Usage
Uses
Used in Organic Chemistry:
3-BIPHENYL-3',5'-DIFLUORO-ACETIC ACID is used as a building block for the synthesis of new organic molecules with potentially useful properties, such as pharmaceuticals or materials with specific electronic properties. Its unique structure allows for the creation of a variety of compounds with diverse applications.
Used in Coordination Chemistry:
In the field of coordination chemistry, 3-BIPHENYL-3',5'-DIFLUORO-ACETIC ACID is used as a ligand to form stable complexes with various metal ions. This property makes it instrumental in the synthesis of coordination compounds and metal-organic frameworks, which have applications in areas such as catalysis, gas storage, and molecular sensing.
Used in Catalyst Development:
3-BIPHENYL-3',5'-DIFLUORO-ACETIC ACID is utilized as a catalyst in organic reactions due to its ability to facilitate certain chemical transformations. Its catalytic properties are valuable in enhancing the efficiency and selectivity of various organic synthesis processes.
Used in Pharmaceutical Development:
As a component in the development of pharmaceuticals, 3-BIPHENYL-3',5'-DIFLUORO-ACETIC ACID contributes to the creation of new drugs with specific therapeutic properties. Its versatility in forming stable complexes and its potential in electronic properties make it a promising candidate for the design of novel pharmaceutical agents.
Used in Material Science:
In material science, 3-BIPHENYL-3',5'-DIFLUORO-ACETIC ACID is employed in the development of materials with tailored electronic properties. Its ability to form stable complexes and its structural features make it suitable for the creation of materials with applications in electronics, optoelectronics, and other advanced technologies.
Check Digit Verification of cas no
The CAS Registry Mumber 866108-77-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,6,1,0 and 8 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 866108-77:
(8*8)+(7*6)+(6*6)+(5*1)+(4*0)+(3*8)+(2*7)+(1*7)=192
192 % 10 = 2
So 866108-77-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H10F2O2/c15-12-6-11(7-13(16)8-12)10-3-1-2-9(4-10)5-14(17)18/h1-4,6-8H,5H2,(H,17,18)
866108-77-2Relevant academic research and scientific papers
Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase
Kotsikorou, Evangelia,Song, Yongcheng,Chan, Julian M. W.,Faelens, Stephanie,Tovian, Zev,Broderick, Erin,Bakalara, Norbert,Docampo, Roberta,Oldfield, Eric
, p. 6128 - 6139 (2007/10/03)
Trypanosoma brucei, the causative agent of African trypanosomiasis, contains a soluble, vacuolar pyrophosphatase, TbVSP1, not present in humans, which is essential for the growth of bloodstream forms in their mammalian host. Here, we report the inhibition of a recombinant TbVSP1 expressed in Escherichia coli by a panel of 81 bisphosphonates. The IC50 values were found to vary from ～2 to 850 μM. We then used 3D QSAR (comparative molecular field and comparative molecular similarity index; CoMFA and CoMSIA) methods to analyze the enzyme inhibition results. The R2 values for the experimental versus the QSAR-predicted activities were 0.78 or 0.61 for CoMFA and 0.79 or 0.68 for CoMSIA, for two different alignments. The root-mean-square (rms) pIC50 error for the best CoMFA model was 0.41 for five test sets of five activity predictions, which translates to a factor of ～2.6 error in IC50 prediction. For CoMSIA, the rms pIC50 error and error factors were 0.35 and 2.2, respectively. In general, the most active compounds contained both a single aromatic ring and a hydrogen bond donor feature. Thirteen of the more potent compounds were then tested in vivo in a mouse model of T. brucei infection. The most active compound in vivo provided a 40% protection from death with no apparent side effects, suggesting that further development of such compounds may be of interest.
