866115-51-7

Basic information

• Product Name: 4-[5-(1-methyl-piperidin-4-yloxy)-quinazolin-4-ylamino]-phenol
• Synonyms: 4-[5-(1-methyl-piperidin-4-yloxy)-quinazolin-4-ylamino]-phenol
• CAS NO: 866115-51-7
• Molecular Weight: 350.42
• Mol File: 866115-51-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[5-(1-methyl-piperidin-4-yloxy)-quinazolin-4-ylamino]-phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[5-(1-methyl-piperidin-4-yloxy)-quinazolin-4-ylamino]-phenol(866115-51-7)
• EPA Substance Registry System: 4-[5-(1-methyl-piperidin-4-yloxy)-quinazolin-4-ylamino]-phenol(866115-51-7)

Safety Data

• Hazardous Substances Data: 866115-51-7(Hazardous Substances Data)

Upstream product

• 436-72-6 5-fluoroquinazolin-4(3H)-one 
• 106-52-5 N-methyl-4-hydroxypiperidine 
• 524955-69-9 5-(1-methyl-piperidin-4-yloxy)-3H-quinazolin-4-one 

Relevant articles and documents

5-Substituted 4-anilinoquinazolines as potent, selective and orally active inhibitors of erbB2 receptor tyrosine kinase

Starting from a 6,7-substituted quinazoline lead 4, optimisation of 5-substituted quinazolines containing an extended aniline motif led to potent and selective inhibitors of erbB2 receptor tyrosine kinase, and a representative compound 12a inhibited tumour growth in a mouse xenograft model.