866141-72-2Relevant articles and documents
Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists
Gross, Raymond S.,Guo, Zhiqiang,Dyck, Brian,Coon, Tim,Huang, Charles Q.,Lowe, Richard F.,Marinkovic, Dragan,Moorjani, Manisha,Nelson, Jodene,Zamani-Kord, Said,Grigoriadis, Dimitri E.,Hoare, Sam R. J.,Crowe, Paul D.,Bu, Jane Han,Haddach, Mustapha,McCarthy, James,Saunders, John,Sullivan, Robert,Chen, TaKung,Williams, John P.
, p. 5780 - 5793 (2007/10/03)
Antagonists of the corticotropin-releasing factor (CRF) neuropeptide should prove to be effective in treating stress and anxiety-related disorders. In an effort to identify antagonists with improved physicochemical properties, new tricyclic CRF1/sub