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Upstream product

• 94-99-5 2,4-Dichlorobenzyl chloride 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 56441-85-1 4-(2,4-Dichlorbenzyloxy)-benzoesaeureaethylester 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 474104-33-1 4-(2',4'-dichlorobenzyloxy)benzoylhydrazine 

Downstream Products

• 1630012-73-5 C₁₉H₂₁Cl₂N₃O₃ 
• 1630013-20-5 4-butyl-5-(4-(2,4-dichlorobenzyloxy)phenyl)-2H-1,2,4-triazole-3(4H)-one 

Relevant academic research and scientific papers

Synthesis and anticonvulsant activity evaluation of 4-butyl-5-(4- alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones

A series of 4-butyl-5-(4-alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones (6a-6u) was designed and synthesized. The anticonvulsant effects and neurotoxicity of the compounds were evaluated with maximal electroshock test and rotarod test. Among the synthetic compounds, 4-butyl-5-(4-(2-fluorinebenzyl)phenyl)-2H-1,2,4- triazole-3 (4H)-one (6k) was the most potent with ED50 value of 27.4 mg/kg and protective index (PI = TD50/ED50) value of 12.0. Besides the anti-MES efficacy, the potency of compound 6k against seizures induced by pentylenetetrazole (PTZ), 3-mercaptopropionic acid (3-MP), and bicuculline (BIC) was also established, which suggested that the mechanisms of action including enhancing of GABAergic activity might be involved in its anticonvulsant activity.