866155-18-2

Basic information

• Product Name: ethyl 3-(p-tolyl)-1H-indole-2-carboxylate
• Synonyms: ethyl 3-(p-tolyl)-1H-indole-2-carboxylate
• CAS NO: 866155-18-2
• Molecular Weight: 279.338
• Mol File: 866155-18-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 3-(p-tolyl)-1H-indole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(p-tolyl)-1H-indole-2-carboxylate(866155-18-2)
• EPA Substance Registry System: ethyl 3-(p-tolyl)-1H-indole-2-carboxylate(866155-18-2)

Safety Data

• Hazardous Substances Data: 866155-18-2(Hazardous Substances Data)

Upstream product

• 938763-88-3 C₁₂H₁₃N₃O₂ 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 14305-31-8 α-acetyl-4-methylbenzenepropanoic acid ethyl ester 
• 1285559-86-5 ethyl 3-(p-tolyl)pyruvate phenyl hydrazone 
• 28048-29-5 ethyl 3-(2-nitrophenyl)propynoate 

Downstream Products

• 1246775-51-8 11-(p-tolyl)-10H-indolo[1,2-a]indol-10-one 
• 1266898-24-1 3-(p-tolyl)-1H-indole-2-carboxylic acid 
• 1285560-13-5 1-benzyl-5-[3-(4-methyl-phenyl)indol-2-yl]pyrrolidin-2-one 
• 30015-86-2 3-(4-methylphenyl)-1H-indole 

Relevant articles and documents

Regioselective synthesis of 1-alkyl-5-(indol-3-yl- and -2-yl)pyrrolidin-2- ones from available reagents

The reaction under mild conditions of 1-alkyl-5-hydroxypyrrolidin-2-ones with different indoles having a free 3 position leads exclusively to 1-alkyl-5-(indol-3-yl)pyrrolidin-2-ones but if position 3 is occupied to 1-alkyl-5-(indol-2-yl)pyrrolidin-2-ones.

Synthesis of substituted indoles from 2-azidoacrylates and ortho-silyl aryltriflates

2-Azidoacrylates react with benzynes in the presence of PPh3 and CsF to afford substituted indoles in good yields. The reaction involves the formation of iminophosphorane and benzyne and a subsequent double cyclization/hydrolysis/air-oxidation cascade. This methodology was utilized to synthesize 10H-indolo[1,2-a]indol-10-ones.