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Usage

Uses

Used in Pharmaceutical Industry:
Benzeneacetic acid, 4-chloro-a-(1-Methylethyl)-, Methyl ester is used as an intermediate in the synthesis of various pharmaceuticals for its potential anti-inflammatory and analgesic properties.
Used in Agrochemical Industry:
Benzeneacetic acid, 4-chloro-a-(1-Methylethyl)-, Methyl ester is used as a precursor in the production of various agrochemicals.
It is important to handle Benzeneacetic acid, 4-chloro-a-(1-Methylethyl)-, Methyl ester with care, as it can be toxic and harmful if not used or handled properly.

Upstream product

• 75-30-9 2-iodo-propane 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 924-50-5 Methyl 3,3-dimethylacrylate 
• 106-39-8 bromochlorobenzene 
• 67-56-1 methanol 
• 2012-74-0 2-(4-chlorophenyl)-3-methylbutyric acid 
• 140-53-4 p-chlorobenzyl cyanide 

Downstream Products

• 88149-98-8 methyl-2-(4-hydroxyphenyl)-3-methylbutanoate 
• 55332-38-2 S-isopropyl-4-chlorophenylacetic acid 
• 63640-09-5 (R)-2-(4-chlorophenyl)-3-methylbutyric acid 
• 127641-48-9 (S)-2-(4-chlorophenyl)isovaleric acid methyl ester 
• 197018-23-8 (R)-2-(4-Chloro-phenyl)-3-methyl-butyric acid methyl ester 

Relevant academic research and scientific papers

Synthesis and Applications of Unquaternized C-Bound Boron Enolates

A general and facile method to prepare unquaternized C-bound boron enolates by a ligand-controlled O-to-C isomerization is reported. Using this protocol, C-bound pinacolboron enolates have been isolated in pure form for the first time, and have been fully characterized by NMR spectroscopy and X-ray crystallography. In contrast to the general perception, such C-boron enolates are stable without coordinative saturation at the boron. Moreover, C-boron enolates present reactivities that are distinct from the O-boron enolates, and their applications in C-O and C-C bond formations are demonstrated.

(R)-ARYLKYLAMINO DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The present invention relates to selected (R)-arylalkylamino derivatives. These compounds show a surprising potent inhibitory effect on C5a induced human PMN chemotaxis. The compounds of the invention absolutely lack of CXCL8 inhibitory activity. Said com

Asymmemtric Hydrolysis of (+/-)-α-Substituted Carboxylic Acid Esters with Microorganisms

Microorganisms that hydrolyze methyl 2-phenylpropionate (1) or reduce 4-phenyl-2-butanone (3) were screened from 250 type cultures.Several Aspergilli and two bacteria hydrolyzed ester 1, and Asp. sojae IAM 2703 preferentially hydrolyzed (R)-isomer of (+/-)-1, whereas Bacillus subtilis var. niger IFO 3108 and Mycobacterium smegmatis ATCC 10143 preferentially hydrolyzed (S)-isomer.The hydrolysis of the related esters of 1 with these organisms was also examined.