866209-70-3Relevant academic research and scientific papers
Large-scale synthesis of a selective inhibitor of the norepinephrine transporter: Mechanistic aspects of conversion of indolinone diol to indolinone aminoalcohol and process implications
Alimardanov, Asaf,Gontcharov, Alexander,Nikitenko, Antonia,Chan, Anita W.,Ding, Zhixian,Ghosh, Mousumi,Levent, Mahmut,Raveendranath, Panolil,Ren, Jianxin,Zhou, Maotang,Mahaney, Paige E.,McComas, Casey C.,Ashcroft, Joseph,Potoski, John R.
experimental part, p. 880 - 887 (2010/04/22)
Development of a scalable synthesis of WAY-315193 is described. Use of LiHMDS as a base and Ti(O-i-Pr)4 as a Lewis acid was optimal for efficient and reproducible addition of indolinone anion to epoxyalcohol. Conversion of indolinone diol to in
PROCESS FOR PREPARING INDOLINONE PHENYLAMINOPROPANOL DERIVATIVES
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Page/Page column 50-52, (2010/11/30)
Processes are disclosed for preparing indolinone phenylaminopropanol derivatives, particularly chiral indolinone phenylaminopropanol derivatives of the general formula (I). The processes disclosed may be used to prepare, inter alia, 7-fluoro-1 - [(1 S, 2R
