Synthesis and antiviral activity of certain 4-substituted and 2,4-disubstituted 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidines

Article abstract of DOI:10.1021/jm00403a005

Treatment of the sodium salt of 4-chloro-2-(methylthio)pyrrolo[2,3-d]pyrimidine (2) with (2-acetoxyethoxy)methyl bromide (3) has provided 4-chloro-2-(methylthio)-7-[2-acetoxyethoxy)methyl]pyrrolo[2,3-d]pyrim dine (4). Ammonolysis of 4 at room temperature