86627-49-8

Basic information

• Product Name: ({4-ethoxy-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl}thio)-N-(2-hydroxyethyl)acetamide
• CAS NO: 86627-49-8
• Molecular Weight: 376.48
• Mol File: 86627-49-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ({4-ethoxy-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl}thio)-N-(2-hydroxyethyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: ({4-ethoxy-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl}thio)-N-(2-hydroxyethyl)acetamide(86627-49-8)
• EPA Substance Registry System: ({4-ethoxy-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl}thio)-N-(2-hydroxyethyl)acetamide(86627-49-8)

Safety Data

• Hazardous Substances Data: 86627-49-8(Hazardous Substances Data)

Upstream product

• 50892-12-1 ethyl <<4,6-dichloro-2-pyrimidinyl>thio>acetate 
• 50892-23-4 pirinixic acid 
• 50892-49-4 ethyl [(4,6-dihydroxypyrimidin-2-yl)-sulfanyl]acetate 
• 141-43-5 ethanolamine 
• 86627-11-4 <<4-ethoxy-6-<(2,3-dimethylphenyl)amino>-2-pyrimidinyl>thio>acetic acid 
• 91759-33-0 ethyl <<4-chloro-6-<(2,3-dimethylphenyl)oxy>-2-pyrimidinyl>thio>acetate 

Relevant articles and documents

Novel pyrimidine and 1,3,5-triazine hypolipidemic agents

New compounds were synthesized by changing the substituents of a trisubstituted pyrimidine, i.e., [[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid, a potent hypolipidemic agent, impaired, however, by a marked hepatomegaly-inducing effect. The structural variations led to the subsidence (14b, i.e., 4-chloro-2-(dimethylamino)-6-[(2,3-dimethylphenyl)amino]pyrimidine) or to the reduction (18b, [[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]amino]acetic acid) of said untoward effect but still maintained the hypolipidemic effect that, although markedly decreased, still proves significant for serum cholesterol and triglycerides (18b) or for serum triglycerides only (14b).