86639-27-2

Upstream product

• 131217-02-2 4-Benzyloxy-5-brom-3-methoxy-phenylacetaldoxim 
• 101732-85-8 3-Methoxy-4-benzyloxy-5-brom-zimtsaeuremethylester 
• 101728-24-9 3-Methoxy-4-benzyloxy-5-brom-hydrozimtsaeure-methylester 
• 121-33-5 vanillin 
• 73304-09-3 [4-(benzyloxy)-3-bromo-5-methoxyphenyl]methanol 
• 100-39-0 benzyl bromide 
• 2556-04-9 4-(benzyloxy)-3-bromo-5-methoxybenzaldehyde 
• 35320-87-7 5-Brom-ω-nitro-3-methoxy-4-benzyloxy-styrol 
• 2973-76-4 5-bromo-4-hydroxy-3-methoxybenzaldehyde 
• 35320-87-7 4-benzyloxy-5-bromo-3-methoxy-ω-nitrostyrene 
• 86639-26-1 α-<4-benzyloxy-5-bromo-3-methoxyphenyl>β-nitroethane 
• 101595-89-5 3-Methoxy-4-benzyloxy-5-brom-hydrozimtsaeurehydrazid 

Downstream Products

• 436-05-5 (±)-curine 
• 86639-20-5 7-Benzyloxy-1-(5-benzyloxy-2-bromo-4-methoxy-benzyl)-8-bromo-6-methoxy-3,4-dihydro-isoquinoline 
• 38849-47-7 2-(5-Benzyloxy-2-bromo-4-methoxy-phenyl)-N-[2-(4-benzyloxy-3-bromo-5-methoxy-phenyl)-ethyl]-acetamide 

Relevant academic research and scientific papers

A Modular Access to (±)-Tubocurine and (±)-Curine - Formal Total Synthesis of Tubocurarine

Two consecutive Cu-catalyzed Ullmann-type C-O couplings permitted the first successful entry toward the curare alkaloids (±)-tubocurine and (±)-curine. Starting from vanillin, the synthetic sequence comprises 15 linear steps and includes a total of 24 transformations. In addition, the total synthesis of tubocurine represents a formal total synthesis of the famous arrow poison alkaloid tubocurarine.

Synthesis of (+/-)-Scoulerine, (+/-)-Coreximine, (+/-)-Tetrahydropalmatine and Their Monobromo and Dibromo Derivatives

(+/-)-Scoulerine (14), (+/-)-tetrahydropalmatine (15), (+/-)-coreximine (17) and their 1-bromo derivatives (13a), (12b) and (16) and 1,12-dibromo derivatives (13c) and (13d) respectively have been synthesized.Condensation of substituted benzaldehyde (1) w