866394-50-5 Usage
Uses
Used in Pharmaceutical Industry:
(1R)-1-(3,4-DiMethoxyphenyl)-4-hydroxy-2-cyclohexene-1-ethanol 1-(4-Methylbenzenesulfonate) is used as a key intermediate in the synthesis of Mesembrine (M338950), a serotonin-uptake inhibitor. (1R)-1-(3,4-DiMethoxyphenyl)-4-hydroxy-2-cyclohexene-1-ethanol 1-(4-Methylbenzenesulfonate) plays a crucial role in the development of pharmaceuticals targeting the modulation of serotonin levels, which can have potential applications in the treatment of various mental health disorders and mood regulation.
Check Digit Verification of cas no
The CAS Registry Mumber 866394-50-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,6,3,9 and 4 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 866394-50:
(8*8)+(7*6)+(6*6)+(5*3)+(4*9)+(3*4)+(2*5)+(1*0)=215
215 % 10 = 5
So 866394-50-5 is a valid CAS Registry Number.
866394-50-5Relevant academic research and scientific papers
Opening of aryl-substituted epoxides to form quaternary stereogenic centers: Synthesis of (-)-mesembrine
Taber, Douglass F.,He, Yigang
, p. 7711 - 7714 (2007/10/03)
Cycloalkanones are easily converted into aryl-substituted cyclic alkenes by the addition of an aryl Grignard reagent followed by dehydration. These alkenes are good substrates for asymmetric epoxidation. We have found that the addition of allylic and benzylic Grignard reagents can occur preferentially at the benzylic position of the derived epoxides to give the quaternary stereogenic center. This approach led to a short synthesis of the nanomolar serotonin re-uptake inhibitor (-)-mesembrine.
