866412-15-9

Upstream product

• 683-08-9 Diethyl methylphosphonate 
• 56441-55-5 ethyl 4-(benzyloxy)benzoate 
• 100-39-0 benzyl bromide 
• 762-04-9 phosphonic acid diethyl ester 
• 84284-70-8 [4-(benzyloxy)phenyl]acetylene 
• 120-47-8 Ethyl 4-hydroxybenzoate 

Downstream Products

• 866412-20-6 (E)-(S)-1-(4-Benzyloxy-phenyl)-7-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-phenyl)-hept-2-en-1-one 
• 30358-99-7 Centrolobin 
• 866412-21-7 1-(4-Benzyloxy-phenyl)-2-[(2R,6S)-6-(4-methoxy-phenyl)-tetrahydro-pyran-2-yl]-ethanone 

Relevant academic research and scientific papers

Copper/Iron-Catalyzed Aerobic Oxyphosphorylation of Terminal Alkynes Leading to β-Ketophosphonates

A copper/iron-catalyzed oxyphosphorylation of alkynes with H-phosphonates through a radical process was developed. The present protocol provides an attractive approach to β-ketophosphonates in moderate to good yields, with the advantages of readily available substrate, high functional group tolerance and operation simplicity. (Chemical Equation Presented).

Asymmetric synthesis of the pyran antibiotic (-)-centrolobine

An expedient total synthesis of (-)-centrolobine is achieved involving asymmetric Keck allylation and stereoselective intramolecular oxy-Michael reactions as key steps in 8% overall yield.