866456-21-5

Upstream product

• 98303-20-9 1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid 
• 615-36-1 2-bromoaniline 

Downstream Products

• 866456-55-5 4-methylene-1-oxo-2-phenyl-2,6-diaza-spiro[4.5]decane-6-carboxylic acid tert-butyl ester 
• 866456-26-0 piperidine-2-carboxylic acid allyl-(2-bromo-phenyl)-amide 
• 866456-51-1 2-[(2-bromo-phenyl)-prop-2-ynyl-carbamoyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 866456-24-8 2-[allyl-(2-bromo-phenyl)-carbamoyl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Practical synthesis of quinoxalinones via palladium-catalyzed intramolecular N-arylations

A practical and highly efficient route to the synthesis of pharmaceutically interesting quinoxalinone scaffolds is reported. The key step involves an intramolecular palladium-catalyzed N-arylation under microwave irradiation. The developed methodology tolerates a variety of bromoanilides to afford a diverse collection of bicyclic and polycyclic quinoxalinones in high yield.

Synthesis of aza/oxaspiro-γ-lactams by radical translocation cyclization reactions

A cascade radical translocation cyclization of the N-allyl-N-(2′- bromophenyl)amide moiety of heterocyclic carboxylic acids and its N-propynyl analogues were investigated. It provides a convenient method for the preparation of aza/oxaspiro-γ-lactams that