866476-35-9Relevant academic research and scientific papers
An improved synthesis of (2E,4Z)-6-(benzyloxy)-4-bromohexa-2,4-dien-1-ol
Clarke, Paul A.,Rolla, Gabriele A.,Cridland, Andrew P.,Gill, Andrew A.
, p. 9124 - 9128 (2008/02/10)
An improved synthesis of (2E,4Z)-6-(benzyloxy)-4-bromohexa-2,4-dien-1-ol has been devised. This new route increases the throughput and yield of the diene product by circumventing a low yielding preparation of boronic acid intermediate as well as removing the need to use multi-gram quantities of highly toxic thallium salts. In the process of developing this new route, a higher yielding preparation of (E)-3-hydroxyprop-1-enylboronic acid was also achieved.
A racemic synthesis of an AB-ring system of hexacyclinic acid
Clarke, Paul A.,Cridland, Andrew P.
, p. 4221 - 4224 (2007/10/03)
(Chemical Equation Presented) An AB-ring system of the polyketide natural product hexacyclinic acid has been synthesized in racemic form. The key steps were an intramolecular Diels-Alder cyclization of an ester tethered 1,3-nonadiene-8-yne, which generate
