866487-70-9Relevant academic research and scientific papers
Rhodium-catalyzed asymmetric hydroformylation of 1,1-disubstituted allylphthalimides: A catalytic route to β3-amino acids
Zheng, Xin,Cao, Bonan,Liu, Tang-Lin,Zhang, Xumu
supporting information, p. 679 - 684 (2013/04/10)
The high enantioselective rhodium-catalyzed hydroformylation of 1,1-disubstituted allylphthalimides has been developed. By employing chiral ligand 1,2-bis[(2S,5S)-2,5-diphenylphospholano]ethane [(S,S)-Ph-BPE], a series of β3-aminoaldehydes can be prepared with up to 95% enantioselectivity. This asymmetric procedure provides an efficient alternative route to prepare chiral β3-amino acids and alcohols. Copyright
Convenient divergent strategy for the synthesis of TunePhos-type chiral diphosphine ligands and their applications in highly enantioselective Ru-catalyzed hydrogenations
Sun, Xianfeng,Zhou, Le,Li, Wei,Zhang, Xumu
, p. 1143 - 1146 (2008/09/18)
(Chemical Equation Presented) A convenient, divergent strategy for the synthesis of a series of modular and fine-tunable C3-TunePhos-type chiral diphosphine ligands and their applications in highly efficient Rucatalyzed asymmetric hydrogenations were explored. Up to 97 and 99% ee values were achieved for the enantioselective synthesis of β-methyl chiral amines and α-hydroxy acid derivatives, respectively.
Enantioselective hydrogenation of allylphthalimides: An efficient method for the synthesis of β-methyl chiral amines
Wang, Chun-Jiang,Sun, Xianfeng,Zhang, Xumu
, p. 4933 - 4935 (2007/10/03)
(Chemical Equation Presented) High yields and up to 98% ee have been achieved by asymmetric hydrogenation of allylphthalimides followed by hydrolysis to give β-methyl chiral amines by using a Ru-C3-tunephos catalyst (see scheme). The synthetic utility of this procedure has been demonstrated through the synthesis of the key intermediate of the LTs receptor antagonist (Zeneca ZD 3532).
