866541-93-7

Usage

Uses

Used in Cancer Treatment:
AT-101 is used as a cancer therapeutic agent for its ability to induce apoptosis in cancer cells, inhibit tumor growth, and enhance the efficacy of other chemotherapeutic agents. It is particularly effective in overcoming drug resistance in cancer cells.
Used in Pharmaceutical Industry:
AT-101 is used as a research compound for the development of novel cancer treatments and drug delivery systems. Its potential to target anti-apoptotic Bcl-2 proteins makes it a valuable tool in the discovery of new therapeutic strategies for various types of cancer.
Used in Hepatitis C and HIV Treatment:
AT-101 is used as a potential therapeutic agent for the treatment of hepatitis C and HIV. Its preclinical studies have shown promising results, indicating its potential to be a valuable addition to the treatment options for these diseases.

Upstream product

• 303-45-7 (rac)-gossypol 
• 64-19-7 acetic acid 

Downstream Products

• 784206-41-3 apogossypol 
• 4547-72-2 gossypolone 
• 109046-69-7 1,6,7,1',6',7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2']binaphthyl-8,8'-dicarbaldehyde bis-(4-acetyl-phenylimine) 
• 114309-69-2 1,1‘,6,6’,7,7’-hexahydroxy-5,5’-diisopropyl-3,3-dimethyl-2,2’-binaphthalene-8-carbaldehyde 
• 105201-55-6 acetic acid 1,7,1',6',7'-pentaacetoxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2']binaphthalenyl-6-yl ester 
• 4649-82-5 6,6',7,7'-Tetrahydroxy-5,5'-diisopropyl-3,3'-dimethyl-8,8'-bis-(phenylimino-methyl)-(2,2'-binaphthalin)-1,1',4,4'-tetraon 
• 303-45-7 (rac)-gossypol 

Relevant academic research and scientific papers

A gossypol derivatives and their use in inhibiting urease activity

The invention relates to the technical field of fertilizer, and particularly relates to gossypol derivatives and an application thereof in inhibition of urease activity. The gossypol derivatives have the chemical structural general formula described in the specification, wherein R represents a part except amino in amino acid, and the amino acid is amino acid containing primary amino. The gossypol derivatives take gossypol as an aldehyde group providing reagent and are prepared by modifying the aldehyde group of gossypol with the amino of the amino acid. When the gossypol derivatives are applied in preparation of urease inhibitors, the urease inhibition effect is good, and the IC50 value inhibiting soil ammonia volatilization effect is as low as 1.56*10 mol.L. Compared with a gossypol raw material, the gossypol derivatives have better solubility, are more stable and are convenient to use; and a part of gossypol derivatives have the urease inhibition activity significantly enhanced.

PRODUCTION OF GOSSYPOL CO-CRYSTALS

This invention relates to relates to methods for producing gossypol acetic acid co- crystals and (-)-gossypol acetic acid co-crystals. The invention also relates to pharmaceutical compositions comprising gossypol acetic acid co-crystals and (-)-gossypol a