866562-71-2

Basic information

• Product Name: 2-{4-[(3-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-N,N-diphenyl-acetamide
• CAS NO: 866562-71-2
• Molecular Weight: 496.052
• Mol File: 866562-71-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{4-[(3-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-N,N-diphenyl-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{4-[(3-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-N,N-diphenyl-acetamide(866562-71-2)
• EPA Substance Registry System: 2-{4-[(3-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-N,N-diphenyl-acetamide(866562-71-2)

Safety Data

• Hazardous Substances Data: 866562-71-2(Hazardous Substances Data)

Upstream product

• 70558-10-0 1-((3-chlorophenyl)(phenyl)methyl)piperazine 
• 6335-34-8 2-bromo-N,N-diphenylacetamide 

Relevant articles and documents

Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors

A novel series of compounds derived from the previously reported N-type calcium channel blocker NP118809 (1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one) is described. Extensive SAR studies resulted in compounds with IC50 values in the range of 10-150 nM and selectivity over the L-type channels up to nearly 1200-fold. Orally administered compounds 5 and 21 exhibited both anti-allodynic and anti-hyperalgesic activity in the spinal nerve ligation model of neuropathic pain.