86661-24-7Relevant academic research and scientific papers
Asymmetric michael addition of ketones to alkylidene malonates and allylidene malonates via enamine - Metal lewis acid bifunctional catalysis
Liu, Lu,Sarkisian, Ryan,Xu, Zhenghu,Wang, Hong
supporting information, p. 7693 - 7699 (2012/11/07)
Novel enamine-metal Lewis acid bifunctional catalysts were successfully applied to the asymmetric Michael addition of ketones to alkylidene malonates, offering excellent stereoselectivity (up to >99% ee and >99:1 dr). The asymmetric Michael addition of ketones to allylidene malonates was also achieved.
Enantioselective organocatalytic Michael Addition of ketones to alkylidene malonates
Syu, Siang-En,Huang, Chan-Hui,Chen, Ko-Wei,Lee, Chia-Jui,Das, Utpal,Jang, Yeong-Jiunn,Lin, Wenwei
experimental part, p. 600 - 605 (2012/10/07)
Organocatalysts bearing sulfide or sulfone functions () were studied for the direct asymmetric Michael addition of ketones and alkylidene malonates. The organocatalyst (S)-2-((naphthalen-2-ylthio)methyl)pyrrolidine, bearing a pyrrolidine and a sulfide moi
Highly enantioselective michael addition of ketone to alkylidene malonates catalyzed by binaphthyl sulfonimides in water
Jia, Shengjian,Luo, Chunhua,Du, Daming
, p. 2676 - 2680 (2013/01/15)
Binaphthyl sulfonimides have been developed to catalyze the asymmetric Michael addition of ketone to alkylidene malonates, affording the corresponding Michael products in good to high yields (up to 98%) with good to excellent diastereoselectivity (up to 9
Highly enantioselective conjugate addition of ketones to alkylidene malonates catalyzed by a pyrrolidinyl-camphor-derived organocatalyst
Magar, Dhananjay R.,Chang, Chihliang,Ting, Ying-Fang,Chen, Kwunmin
supporting information; experimental part, p. 2062 - 2066 (2010/06/15)
Pyrrolidinyl-camphor derivatives have been proven to be efficient organocatalysts for enantioselective conjugate addition of ketones to alkylidene malonates, affording high chemical yields (up to 95 %) of the corresponding products with high to excellent levels of diastereoselectivity (up to >99:1 dr) and enantioselectivity (up to 96%ee) under solvent-free reaction conditions at ambient temperature.
Asymmetric Michael Additions. Stereoselective Alkylations of the (R)- and (S)-Enamine from Cyclohexanone and 2-(Methoxymethyl)pyrrolidine by Methyl α-(Methoxycarbonyl)cinnamates
Blarer, Stefan J.,Seebach, Dieter
, p. 2250 - 2260 (2007/10/02)
Alkylation of (2S)-1-(1-cyclohexen-1-yl)-2-(methoxymethyl)pyrrolidine ((S)-1, enamine from cyclohexanone and 2-(methoxymethyl)pyrrolidine) by the Knoevenagel condensation products 4 of aromatic aldehydes yields 35-76percent of Michael adducts (1 + 4 -> ->
