86662-01-3

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 96-96-8 4-methoxy-2-nitroaniline 
• 104-94-9 4-methoxy-aniline 
• 4284-48-4 N-(4-methoxyphenyl)methanesulfonamide 

Downstream Products

• 22736-68-1 N-(4-Methoxy-2-nitro-phenyl)-N-(1,1,2,2-tetrachloro-2-fluoro-ethylsulfanyl)-methanesulfonamide 
• 86662-00-2 N-(2-Bromo-ethyl)-N-(4-methoxy-2-nitro-phenyl)-methanesulfonamide 
• 344301-47-9 N-(2-Amino-4-methoxy-phenyl)-N-(2-bromo-ethyl)-methanesulfonamide 
• 344337-07-1 N-(2-Bromo-ethyl)-N-(2-isothiocyanato-4-methoxy-phenyl)-methanesulfonamide 
• 1137520-48-9 N-[(Z)-(4-tert-butyldiphenylsilanyloxy)but-2-enyl]-(4-methoxy-2-nitrophenyl)methanesulfonamide 

Relevant academic research and scientific papers

Mild hypervalent iodine mediated oxidative nitration of N-aryl sulfonamides

An oxidative and acid-free method for the nitration of N-aryl sulfonamides has been developed using a combination of sodium nitrite as cheap and easy to handle NO2-source and the hypervalent iodine reagent PIFA as stoichiometric oxidant. Under

Reduction of arenediazonium salts by tetrakis(dimethylamino)ethylene (TDAE): Efficient formation of products derived from aryl radicals

Tetrakis(dimethylamino)ethylene (TDAE 1), has been exploited for the first time as a mild reagent for the reduction of arenediazonium salts to aryl radical intermediates through a single electron transfer (SET) pathway. Cyclization of the aryl radicals produced in this way led, in appropriate substrates, to syntheses of indolines and indoles. Cascade radical cyclizations of aryl radicals derived from arenediazonium salts are also reported. The relative ease of removal of the oxidized by-products of TDAE from the reaction mixture makes the methodology synthetically attractive.