866641-27-2

Basic information

• Product Name: ethyl (5-phenyl-1,2-oxazol-3-yl)methyl methanesulfonate
• Synonyms: ethyl (5-phenyl-1,2-oxazol-3-yl)methyl methanesulfonate
• CAS NO: 866641-27-2
• Molecular Weight: 253.279
• Mol File: 866641-27-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl (5-phenyl-1,2-oxazol-3-yl)methyl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (5-phenyl-1,2-oxazol-3-yl)methyl methanesulfonate(866641-27-2)
• EPA Substance Registry System: ethyl (5-phenyl-1,2-oxazol-3-yl)methyl methanesulfonate(866641-27-2)

Safety Data

• Hazardous Substances Data: 866641-27-2(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 1619-37-0 (5-phenylisoxazol-3-yl)methanol 
• 124-63-0 methanesulfonyl chloride 
• 942-68-7 3-methoxy-5-phenylisoxazole 
• 7063-99-2 ethyl 5-phenylisoxazole-3-carboxylate 

Relevant articles and documents

PHENOXYACETIC ACID DERIVATIVES AND DRUGS USING THE SAME

It is intended to provide a novel compound having an excellent agonism to PPARs α/γ and desirable properties as a drug. An agonist to peroxisome proliferator-activated receptors α/γ which is represented by the general formula (I) (wherein Q represents an optionally substituted benzene ring or pyridine ring; R1 and R2 represent each an optionally substituted phenyl group or a 5- to 6-membered aromatic heterocycle group; X, Y and Z independently represent each C, O, S or N; R3 to R9 represent each a hydrogen atom, a lower alkyl group, etc.; and n is an integer of from 0 to 3.

Novel 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)-xanthine derivatives as high affinity and selective A2B adenosine receptor antagonists

A series of new 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)- xanthine derivatives as A2B-AdoR antagonists have been synthesized and evaluated for their binding affinities for the A2B, A 1, A2A, and A3-AdoRs. 8-(1-((3-phenyl-1,2,4- oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione (4) displayed high affinity (Ki = 1 nM) and selectivity for the A2B-AdoR versus A1, A2A, and A 3-AdoRs (A1/A2B, A2A/A2B, and A3/A2B selectivity ratios of 370, 1100, and 480, respectively). The synthesis and SAR of this novel class of compounds are presented herein.