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Usage

Uses

Used in Organic Synthesis:
2-Fluoro-5-iodophenylboronic acid is used as a key intermediate in organic synthesis for the creation of complex organic molecules. Its unique structure allows for selective reactions and the formation of various functional groups, making it a valuable component in the synthesis of specialty chemicals.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-Fluoro-5-iodophenylboronic acid is employed as a building block for the design and synthesis of novel pharmaceuticals. Its presence in the molecular structure can influence the pharmacokinetic and pharmacodynamic properties of drug candidates, contributing to improved therapeutic efficacy and safety profiles.
Used in Drug Discovery and Development:
2-Fluoro-5-iodophenylboronic acid plays a crucial role in drug discovery and development, where it is utilized to construct and optimize lead compounds. Its unique chemical properties enable the exploration of new chemical space and the identification of potential drug candidates with enhanced potency and selectivity.
Used in the Production of Advanced Materials:
This boronic acid derivative is also used in the production of advanced materials, such as polymers, coatings, and sensors. Its ability to form stable bonds with various elements allows for the development of materials with tailored properties for specific applications.
Used in the Development of Bond Formation Methods:
2-Fluoro-5-iodophenylboronic acid is utilized in the development of new methods for carbon-carbon and carbon-heteroatom bond formation. These innovative approaches can improve the efficiency and selectivity of chemical reactions, facilitating the synthesis of complex molecules and the advancement of chemical research.

Upstream product

• 352-34-1 4-fluoro-1-iodobenzene 

Downstream Products

• 1361033-33-1 1-(2-fluoro-5-iodophenyl)-4,8-dimethylnon-7-en-3-one 
• 1361033-32-0 1-(2-fluoro-5-iodophenyl)octan-3-one 
• 186589-89-9 5-iodo-2-fluorophenol 

Relevant academic research and scientific papers

NEW COMPOUND

PROBLEM TO BE SOLVED: To provide a new compound that does not have structural similarity to ceramide and has excellent CERT inhibitory activity. SOLUTION: The present invention provides a new compound of structural formula (I). A bond group -X- is cis-cyclopropyl-, R1, R2, R3, R4, and R5 independently represent a hydrogen atom, a halogen atom, a linear or branched C1-C8 alkyl group that may have a halogen atom, or OR6. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2020,JPOandINPIT

PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS

The present invention is directed toward pyridyl derivatives of formula (I) as antagonists of the mGlu5 receptor. As such the compounds may be useful for treatment or prevention of disorders remedied by antagonism of the mGlu5 receptor, wherein Ar is phenyl or napthyl each of which may be substituted by one or more C1-C4 alkyl, C1-C4 alkoxy, C1-C5 acyl, halo, amino, nitro, cyano, hydroxy, C1-C5 acylamino, C1-C4 alkylsulfonylamino, mono-, di- or trifluorinated C1-C3 alkyl, substituents which may be the same or different and may bear a CONH2, CONHCH3, CON(CH3)2, CO2H, CO2CH3, OCF3, CH2NHCOCH3, CH2NH2, CH2N(CH3)2, CH2CN, CH2OH, CH2NHSO2CH3, CH2N(CH3)(CH2)2 CN, CH2N(CH3)CH(CH3)2, CH2NHCH(CH3)2, CH2NH(CH2)2CH3, CH2NHCO2R4, CH2NHCH2CH3, CH2NHCH3 NHCOC(CH3)2, or N(S(O)2CH3)2 substituent; R1 is hydrogen, halo, R4, CN, C(NOH)R3, C(NO-R4)R3, (CH)2CO2R4 , (CH2)n OR3 , COR3 , CF3,SR4 , S(O)R4, S(O)2R4, COCH2CO2R3 , NHSO2R4 , NHCOR3, C(NOR3)NH2, CH2OCOR3,(CH2)n NH2, CON(CH3)2 (CH2)nNHCO2R4 , CO2R3, CONH2, CSNH2, C(NH)NHOR3, (CH2)nN(CH3)2, or CONHNHCOR3; R2 is 1,2-ethenediyl or 1,2-ethynediyl; R3 is hydrogen or C1-C4 alkyl; R4 is C1-C4 alkyl; and n is 0, 1, 2,3 or 4; or a pharmaceutically acceptable salt thereof, or an N-oxide thereof.