866684-98-2

Upstream product

• 626-55-1 3-Bromopyridine 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 2510-23-8 3-Ethynylpyridine 
• 352-34-1 4-fluoro-1-iodobenzene 
• 706-06-9 3-(4-flurophenyl)prop-2-ynoic acid 

Relevant academic research and scientific papers

Controlling π-πInteractions through coordination bond formation: Assembly of 1-d chains of acac-Based coordination compounds

We present a new approach for the construction of 1-D chains of acac-based copper coordination compounds assembled through π-πaromatic interactions. We use 3-(phenylethynyl)pyridine derivatives as ligands that can establish aromatic interactions to intermolecularly bind the coordination compounds. The crystal networks of the free pyridines show that there is no control over aromatic interactions, since different interactions are present. On the other hand, the supramolecular behavior of the coordination compounds is very homogeneous since, in all of the crystal networks, the intended 1-D chains are present. Given the polarization of the aromatic rings due to coordination, reflected in the calculated molecular electrostatic potential maps, we gain control over the ?-πinteraction geometry, promoting a head to tail interaction between the coordinated 3-(phenylethynyl)pyridines. This strategy to constructing 1-D chains is reliable and reproducible; thus, these types of π-πaromatic interactions are a useful supramolecular tool to control the molecular assembly in the solid state.

Rh-catalyzed decarbonylation of conjugated ynones via carbon-alkyne bond activation: Reaction scope and mechanistic exploration via DFT calculations

In this full article, detailed development of a catalytic decarbonylation of conjugated monoynones to synthesize disubstituted alkynes is described. The reaction scope and limitation has been thoroughly investigated, and a broad range of functional groups

Phosphine-free palladium-catalyzed decarboxylative coupling of alkynylcarboxylic acids with aryl and heteroaryl halides

We herein report the design and development of a carboxyamido/carbene ligand and its Pd-complex for the decarboxylative coupling of alkynylcarboxylic acids with aryl and heteroaryl halides to afford arylalkynes. Copyright

Efficient synthesis of biologically interesting 3,4-diaryl-substituted succinimides and maleimides: Application of iron-catalyzed carbonylations

A straightforward two-step synthesis of trans-3,4-disubstituted succin imides through a palladium-catalyzed Sonogashira reaction and an iron-catalyzed double carbonylation is described. In situ oxidative dehydrogenation gave the corresponding 3,4-diarylmaleimides. By starting from readily available aryl and hetgeroaryl halides, a variety of new analogues and derivatives of bioactive 3,4-bisindolylmaleimides are obtained in good yield and selectivity.

PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS

The present invention is directed toward pyridyl derivatives of formula (I) as antagonists of the mGlu5 receptor. As such the compounds may be useful for treatment or prevention of disorders remedied by antagonism of the mGlu5 receptor, wherein Ar is phenyl or napthyl each of which may be substituted by one or more C1-C4 alkyl, C1-C4 alkoxy, C1-C5 acyl, halo, amino, nitro, cyano, hydroxy, C1-C5 acylamino, C1-C4 alkylsulfonylamino, mono-, di- or trifluorinated C1-C3 alkyl, substituents which may be the same or different and may bear a CONH2, CONHCH3, CON(CH3)2, CO2H, CO2CH3, OCF3, CH2NHCOCH3, CH2NH2, CH2N(CH3)2, CH2CN, CH2OH, CH2NHSO2CH3, CH2N(CH3)(CH2)2 CN, CH2N(CH3)CH(CH3)2, CH2NHCH(CH3)2, CH2NH(CH2)2CH3, CH2NHCO2R4, CH2NHCH2CH3, CH2NHCH3 NHCOC(CH3)2, or N(S(O)2CH3)2 substituent; R1 is hydrogen, halo, R4, CN, C(NOH)R3, C(NO-R4)R3, (CH)2CO2R4 , (CH2)n OR3 , COR3 , CF3,SR4 , S(O)R4, S(O)2R4, COCH2CO2R3 , NHSO2R4 , NHCOR3, C(NOR3)NH2, CH2OCOR3,(CH2)n NH2, CON(CH3)2 (CH2)nNHCO2R4 , CO2R3, CONH2, CSNH2, C(NH)NHOR3, (CH2)nN(CH3)2, or CONHNHCOR3; R2 is 1,2-ethenediyl or 1,2-ethynediyl; R3 is hydrogen or C1-C4 alkyl; R4 is C1-C4 alkyl; and n is 0, 1, 2,3 or 4; or a pharmaceutically acceptable salt thereof, or an N-oxide thereof.