866755-93-3Relevant academic research and scientific papers
Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations
Ersmark, Karolina,Nervall, Martin,Hamelink, Elizabeth,Janka, Linda K.,Clemente, Jose C.,Dunn, Ben M.,Blackman, Michael J.,Samuelsson, Bertil,?qvist, Johan,Hallberg, Anders
, p. 6090 - 6106 (2007/10/03)
A series of inhibitors of the malarial aspartic proteases Plm I and II have been synthesized with L-mannitol as precursor. These inhibitors are characterized by either a diacylhydrazine or a five-membered oxadiazole ring replacing backbone amide functiona
