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Usage

Uses

Used in Pharmaceutical Research:
(PYRROL-3-YL)-ACETIC ACID is used as a research compound for its potential therapeutic applications, including its anti-inflammatory properties and its ability to inhibit the growth of cancer cells. Its unique structure allows it to interact with biological targets, making it a valuable candidate for drug development.
Used in Organic Synthesis:
In the field of organic synthesis, (PYRROL-3-YL)-ACETIC ACID serves as a key intermediate or building block in the creation of more complex organic molecules. Its reactivity and functional groups make it suitable for various synthetic pathways.
Used in Neurological Disorder Treatment:
(PYRROL-3-YL)-ACETIC ACID is used as a potential therapeutic agent in the treatment of neurological disorders. Its investigation in this area is due to its capacity to modulate certain biological processes relevant to neurological health.
Used in Scientific Research:
In scientific research, (PYRROL-3-YL)-ACETIC ACID is utilized to study its chemical properties and interactions with biological systems. This helps in understanding its potential applications and limitations in various fields of study.
Used in Industrial Applications:
(PYRROL-3-YL)-ACETIC ACID finds use in industrial applications where its chemical properties are leveraged for specific processes or products, such as in the development of new materials or chemical intermediates for various industries.

InChI:InChI=1/C6H7NO2/c8-6(9)3-5-1-2-7-4-5/h1-2,4,7H,3H2,(H,8,9)

Upstream product

• 87630-41-9 ethyl 2-oxo-2-(1H-pyrrol-3-yl)acetate 
• 71616-57-4 ethyl 2-(3-pyrrolyl)acetate 
• 81453-98-7 3-acetyl-1-(phenylsulfonyl)pyrrole 
• 106058-85-9 1-(1-tosyl-1H-pyrrol-3-yl)ethan-1-one 
• 138779-98-3 N-tosyl-(1H-pyrrol-3-yl)acetic acid methyl ester 
• 86688-97-3 1-(Phenylsulfonyl)-3-(carbomethoxymethyl)pyrrole 

Downstream Products

• 134226-30-5 N-(m-vinylphenyl)-1-H-pyrrole-3-acetamide 
• 134226-28-1 N-(p-vinylphenyl)-1-H-pyrrole-3-acetamide 
• 50-00-0 formaldehyd 
• 132081-36-8 N-(pyrryl-3)acetyl-2-phenylglycine methyl ester 
• 1594128-72-9 C₂₈H₃₃N₃O₃ 
• 1253640-93-5 4-((3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctylthio)carbonyl)-phenyl 2-(1H-pyrrol-3-yl)acetate 
• 1253640-92-4 4-((3,3,4,4,5,5,6,6,6-nonafluorohexylthio)carbonyl)phenyl 
• 1253640-94-6 4-((3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecylthio)carbonyl)-phenyl 2-(1H-pyrrol-3-yl)acetate 
• 313663-81-9 4,6-dihydrocyclopenta[b]pyrrol-5(1H)-one 
• 1414702-04-7 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)ethyl 2-(1H-pyrrol-3-yl)acetate 

Relevant academic research and scientific papers

Design, synthesis, and evaluation of 3-aryl-4-pyrrolyl-maleimides as glycogen synthase kinase-3β inhibitors

A series of 3-aryl-4-pyrrolyl-maleimides were designed, synthesized, and evaluated for their glycogen synthase kinase-3β (GSK-3β) inhibitory activity. Most compounds exhibited potent activity against GSK-3β. Among them, compounds 11a, 11c, 11h, 11i, and 11j significantly reduced Aβ-induced Tau hyperphosphorylation, showing the inhibition of GSK-3β at the cellular level. Structure-activity relationships were discussed based on the experimental data obtained. Most compounds in a new series of 3-aryl-4-pyrrolyl-maleimides exhibited potent glycogen synthase kinase-3β (GSK-3β) inhibitory activity. Compounds 11a, 11c, 11h, 11i, and 11j reduced Aβ-induced Tau hyperphosphorylation, showing inhibition of GSK-3β at the cellular level. Copyright

Synthesis of novel pyrrolyl-indomethacin derivatives

In the present work, we report the synthesis of the novel esters of indomethacin (IDMC) and an ester of reduced IDMC. For this purpose, IDMC is covalently bound by using a spacer chain to the pyrrole (Py) in the 3-position. The innovative pyrrole-indomethacin (3-Py-IDMC) derivates show no cytotoxic effects in primary calvarial osteoblasts. The designed IDMC derivates have been studied because they could be injected locally as a component of polymeric micro-particles. In fact, the new 3-Py-IDMC derivatives will assure their further polymerization since the 2- and 5-monomer positions are free.

Superhydrophobic surfaces of electrodeposited polypyrroles bearing fluorinated liquid crystalline segments

Two intrinsic properties of fluorinated tails (F-butyl to F-octyl) were combined in the elaboration of superhydrophobic surfaces by electrochemical polymerization: their promesogenic characteristic and their ability to increase both hydrophobicity and oleophobicity. We report the synthesis and the characterization of pyrrole monomers bearing fluorinated liquid crystalline segments. The electrodeposited corresponding polymer films were characterized by cyclic voltammetry, static and dynamic contact angle measurements, and scanning electron microscopy. Sticky superhydrophobic surfaces were obtained with a F-hexyl or a F-octyl tail. The presence of mesogenic segments improves the surface hydrophobicity and increases the surface roughness, clearly observed with F-butyl and F-hexyl chains.

Synthesis and polymerization of 2-(3-pyrrolyl)acetic acid derivatives from pyrrole

The synthesis of the 3-pyrrylacetic acid as well as the study of its esterification conditions are described. The new materials thus obtained are electropolymerized.

Poly[(3-pyrrolyl)acetic acid]

A poly[(3-pyrrolyl)acetic acid] is here disclosed which is represented by the formula (I) STR1 wherein n is an integer of 2 or more. This polymer can be prepared by subjecting (3-pyrrolyl)acetic acid to electrolytic oxidation polymerization in the presenc

Regioselective Synthesis of Acylpyrroles

The regioselective synthesis of several pyrrole derivatives is described.AlCl3-catalyzed acylation reactions of 1-(phenylsulfonyl)pyrrole (1) give 3-acyl derivatives, whereas the corresponding BF3*OEt2-catalyzed reactions give 2-acyl derivatives predominantly.Mild alkaline hydrolysis gives the corresponding acyl-1H-pyrroles in excellent yields.AlCl3-catalyzed reactions of 1 with 1,1-dichloromethyl methyl ether and oxalyl chloride give 1-(phenylsulfonyl)-2-formylpyrrole (6) and 1-(phenylsulfonyl)-2-(chlorocarbonyl)pyrrole (7), respectively. 3-Pyrrolylacetic acid (10) was prepared by thallium(III) nitrate promoted rearrangement of 1-(phenylsulfonyl)-3-acetylpyrrole (2a).Trifluoroacetic anhydride catalyzed cyclization of 4-butyric acid (14) gives 1-(phenylsulfonyl)-7-oxo-4,5,6,7-tetrahydroindole (17).Attempts to cyclize 14 at the 4-position have been unsuccessful.