86688-98-4Relevant academic research and scientific papers
Regioselective Synthesis of Acylpyrroles
Kakushima, Masatoshi,Hamel, Pierre,Frenette, Richard,Rokach, Joshua
, p. 3214 - 3219 (1983)
The regioselective synthesis of several pyrrole derivatives is described.AlCl3-catalyzed acylation reactions of 1-(phenylsulfonyl)pyrrole (1) give 3-acyl derivatives, whereas the corresponding BF3*OEt2-catalyzed reactions give 2-acyl derivatives predominantly.Mild alkaline hydrolysis gives the corresponding acyl-1H-pyrroles in excellent yields.AlCl3-catalyzed reactions of 1 with 1,1-dichloromethyl methyl ether and oxalyl chloride give 1-(phenylsulfonyl)-2-formylpyrrole (6) and 1-(phenylsulfonyl)-2-(chlorocarbonyl)pyrrole (7), respectively. 3-Pyrrolylacetic acid (10) was prepared by thallium(III) nitrate promoted rearrangement of 1-(phenylsulfonyl)-3-acetylpyrrole (2a).Trifluoroacetic anhydride catalyzed cyclization of 4-butyric acid (14) gives 1-(phenylsulfonyl)-7-oxo-4,5,6,7-tetrahydroindole (17).Attempts to cyclize 14 at the 4-position have been unsuccessful.
PYRROLE COMPOSITIONS USEFUL AS INHIBITORS OF C-MET
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Page/Page column 37, (2010/02/10)
The present invention relates to compounds of the following Formula I, useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for making the compounds and methods
Diels-Alder Reactions of 2,3-Dimethylenepyrrole Analogues; a New Synthesis of Indoles
Jackson, P. Mark,Moody, Christopher J.
, p. 2156 - 2158 (2007/10/02)
The pyranopyrrol-5(1H)-ones (4) are stable cyclic analogues of 2,3-dimethylenepyrrole and undergo Diels-Alder reaction with a range of acetylenes, or acetylene equivalents, to give, after loss of carbon dioxide, indoles.
