86689-67-0Relevant academic research and scientific papers
Mitomycin analogs
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, (2008/06/13)
Antineoplastic compounds of the formula, IIa, STR1 wherein: Y is hydrogen or lower alkyl; and Z is a lower alkoxy substituted quinolinylamino radical, a cyano substituted pyrazolylamino radical or a mono- or di-lower alkyl substituted thiazolamino radical, or a nitrogen-containing heterocyclic radical, or a cyano, phenyl, carboxamido or lower alkoxycarbonyl substituted 1-aziridinyl radical or a lower alkyl, formyl or acetylphenyl substituted 1-piperazinyl radical, or an hydroxy or piperidyl substituted 1-piperidyl radical, or a lower alkoxy, amino or halo substituted pyridylamino radical, or a carboxamido, mercapto or methylenedioxy substituted anilino radical, or a radical of the formula, STR2 wherein R is hydrogen or lower alkyl and R" is a nitrogen-containing heterocyclic radical, or a butyrolactonyl radical, or an adamantyl radical, or a mono- lower alkoxy substituted phenyl radical, or a substituted lower alkyl radical selected from the group consisting of mercapto lower alkyl, carboxy lower alkyl, mono-, di- and tri-lower alkoxy lower alkyl, lower alkyl thio lower alkyl and lower alkoxycarbonyl substituted derivatives thereof, cyano lower alkyl, mono-, di- and tri-lower alkoxy phenyl lower alkyl, phenyl cyclo lower alkyl, 1-pyrrolidinyl lower alkyl, N-lower alkyl pyrrolidinyl lower alkyl, N-morpholinyl lower alkyl, and lower dialkylamino lower alkyl.
Mitomycin C Analogues with Secondary Amines at Position 7
Iyengar, Bhashyam S.,Sami, Salah M.,Tarnow, Shirley E.,Remers, William A.,Bradner, William T.,Schurig, John E.
, p. 1453 - 1457 (2007/10/02)
A series of mitomycin C analogues with secondary amines at position 7 was prepared from mitomycin A.Eleven of the 20 new compounds in this series were more active than mitomycin C against P-388 murine leukemia, and 2 of these 11 were significantly less le
