866942-11-2

Basic information

• Product Name: 2-(2-Methoxyethoxy)ethyl 2-(chlorosulfonyl)benzoate
• Synonyms: 2-(2-Methoxyethoxy)ethyl 2-(chlorosulfonyl)benzoate ;2-(2-Methoxyethoxy)ethyl 2-(chlorosulfonyl)benzoate 97%
• CAS NO: 866942-11-2
• Molecular Formula: C₁₂H₁₅ClO₆S
• Molecular Weight: 322.7619
• Mol File: 866942-11-2.mol
• Article Data: 3

Chemical Properties

• Flash Point: >110℃
• Appearance: /
• Density: 1.525 g/mL at 25 °C
• Refractive Index: n20/D1.312
• CAS DataBase Reference: 2-(2-Methoxyethoxy)ethyl 2-(chlorosulfonyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Methoxyethoxy)ethyl 2-(chlorosulfonyl)benzoate(866942-11-2)
• EPA Substance Registry System: 2-(2-Methoxyethoxy)ethyl 2-(chlorosulfonyl)benzoate(866942-11-2)

Safety Data

• Hazard Codes: C
• Statements: 20/22-34
• Safety Statements: 23-26-36/37/39
• RIDADR: UN 3265 8 / PGIII
• WGK Germany: 2
• Hazardous Substances Data: 866942-11-2(Hazardous Substances Data)

Usage

Molecular Weight

370.83 g/mol The mass of one mole of the chemical.

Chemical Class

Benzoates The chemical belongs to a class of compounds that contain a benzene ring bonded to a carboxylic acid group.

Ester Formation

2-(2-Methoxyethoxy)ethyl alcohol and 2-(chlorosulfonyl)benzoic acid The chemical is an ester formed from the reaction of 2-(2-Methoxyethoxy)ethyl alcohol and 2-(chlorosulfonyl)benzoic acid.

Usage

Intermediate in the production of pharmaceuticals, agrochemicals, and dyestuffs The chemical is used as an intermediate in the production of various chemicals, including pharmaceuticals, agrochemicals, and dyestuffs.

Organic Synthesis

Building block for the production of various chemicals The chemical is used as a building block in organic synthesis for the production of different chemicals.

Oxidizing Agent

Mild oxidizing properties The chemical has the ability to act as a mild oxidizing agent in some chemical reactions.

Upstream product

• 111-77-3 2-(2-methoxyethoxy)ethyl alcohol 
• 34684-21-4 2-chlorosulfonylbenzoyl chloride 
• 81-08-3 2-sulfobenzoic acid cyclic anhydride 

Downstream Products

• 866942-24-7 4-decyl 2-(methoxyethoxyethylcarboxy)-1-benzosulfonate 
• 1146207-10-4 C₂₁H₂₅BrO₇S 
• 888021-85-0 2-(1-benzyl-2-phenyl-ethoxysulfonyl)-benzoic acid 2-(2-methoxy-ethoxy)-ethyl ester 
• 866942-25-8 2-adamantyl 2-(methoxyethoxyethylcarboxy)-1-benzosulfonate 
• 866942-23-6 1-phenyl-2-propyl 2-(methoxyethoxyethylcarboxy)-1-benzosulfonate 
• 1174658-52-6 C₃₉H₆₂O₇S 
• 1174658-50-4 C₂₂H₃₄O₇S 
• 1082742-74-2 C₂₂H₃₄O₇S 
• 1175669-90-5 C₂₂H₃₆O₇S 
• 1174658-46-8 C₂₀H₃₂O₇S 
• 888021-88-3 2-[(3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxysulfonyl]-benzoic acid 2-(2-methoxy-ethoxy)-ethyl ester 
• 888021-89-4 2-cyclododecyloxysulfonyl-benzoic acid 2-(2-methoxy-ethoxy)-ethyl ester 

Relevant articles and documents

NUCLEOPHILE ASSISTING LEAVING GROUPS

Sulfonate leaving groups include a cation chelating moiety, e.g. a polyether or crown ether. The chelating moiety stabilizes the sulfonate leaving group by forming a complex with a cation of a cation-nucleophile combination. The stabilized leaving group is more easily displaced under many conditions than are standard arylsulfonate leaving groups such as the toxyl group. The chelating moiety also favors certain cations depending on the identity of the moiety thereby enhancing the reaction rate with nucleophilic salts containing the preferred cation. Use of the inventive leaving groups results in improved yields, decreased reaction times and improved product purity.

Arylsulfonate-based nucleophile assisting leaving groups

The synthesis and unique reactivity of a series of arylsulfonate-based nucleophile assisting leaving groups (NALG) containing oligomeric ether units (including crown ethers) attached to the arylsulfonyl ring in the ortho orientation are described. The reactions of a variety of these ether-containing alkyl sulfonates with metal halides proceeded at substantially greater rates than electronically similar sulfonates. These ether-containing leaving groups also displayed marked selectivity for lithium halides relative to the corresponding sodium and potassium salts in nucleophilic displacement reactions.