34684-21-4

Basic information

• Product Name: Benzoyl chloride, 2-(chlorosulfonyl)-
• CAS NO: 34684-21-4
• Molecular Formula: C7H4Cl2O3S
• Molecular Weight: 239.079
• Mol File: 34684-21-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoyl chloride, 2-(chlorosulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 2-(chlorosulfonyl)-(34684-21-4)
• EPA Substance Registry System: Benzoyl chloride, 2-(chlorosulfonyl)-(34684-21-4)

Safety Data

• Hazardous Substances Data: 34684-21-4(Hazardous Substances Data)

Upstream product

• 81-08-3 2-sulfobenzoic acid cyclic anhydride 
• 10025-87-3 trichlorophosphate 
• 10026-13-8 phosphorus pentachloride 
• 632-25-7 2-sulfobenzoic acid 
• 6939-89-5 o-sulfobenzoic acid, monoammonium salt 

Downstream Products

• 125-31-5 3,3-bis(4-hydroxy-2,5-dimethylphenyl)-3H-2,1λ⁶-benzoxathiole 1,1-dioxide 
• 15448-99-4 N-methylsaccharin 
• 54075-06-8 2-benzoyl-benzenesulfonyl chloride 
• 81-08-3 2-sulfobenzoic acid cyclic anhydride 
• 7647-01-0 hydrogenchloride 
• 632-25-7 2-sulfobenzoic acid 
• 201216-01-5 phenyl(2-(phenylsulfonyl)phenyl)methanone 
• 15448-98-3 3,3-diphenyl-1,2-benzoxathiole 1,1-dioxide 
• 19298-38-5 N-phenyl-2-phenylsulfamoyl-benzamide 
• 15449-00-0 N-phenylsaccharin 
• 861784-67-0 2-(4-hydroxy-benzoyl)-benzenesulfonic acid 
• 98882-18-9 2-phenoxysulfonyl-benzoic acid phenyl ester 
• 97027-53-7 2-chlorosulfonyl-benzoic acid phenyl ester 

Relevant articles and documents

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METHODS OF TREATING LIVER DISEASES

The invention provides tricyclic compounds and their use in treating liver disorders, such as non-alcoholic steatohepatitis and related disorders (e.g., fibrosis). The compounds are contemplated to have activity against methionyl aminopeptidase 2.

NUCLEOPHILE ASSISTING LEAVING GROUPS

Sulfonate leaving groups include a cation chelating moiety, e.g. a polyether or crown ether. The chelating moiety stabilizes the sulfonate leaving group by forming a complex with a cation of a cation-nucleophile combination. The stabilized leaving group is more easily displaced under many conditions than are standard arylsulfonate leaving groups such as the toxyl group. The chelating moiety also favors certain cations depending on the identity of the moiety thereby enhancing the reaction rate with nucleophilic salts containing the preferred cation. Use of the inventive leaving groups results in improved yields, decreased reaction times and improved product purity.