866993-20-6

Upstream product

• 1517-82-4 (1R,2S,5R,SS)-(-)-menthyl p-toluenesulfinate 
• 100-47-0 benzonitrile 
• 98-86-2 acetophenone 
• 188447-91-8 (S)-p-toluenesulfinimide 

Downstream Products

• 1350547-03-3 (2S,5S)-5-(bromomethyl)-2-methyl-2-phenyl-3-(p-tolylsulfinyl)-1-(p-tolylsulfonyl)-2,5-dihydro-1H-pyrrole 
• 1350547-10-2 (+)-(2S,5R)-5-(bromomethyl)-2-methyl-2-phenyl-3-(p-tolylsulfinyl)-1-(p-tolylsulfonyl)-2,5-dihydro-1H-pyrrole 
• 1350546-90-5 (+)-N-[(2S,3E)-2-phenyl-3-((S)-p-tolylsulfinyl)-3,5-hexadien-2-yl]-4-methylbenzenesulfonamide 
• 1350546-81-4 (+)-(2S,3E)-2-phenyl-3-((S)-p-tolylsulfinyl)hexa-3,5-dien-2-amine 
• 1350546-70-1 (+)-(S)-N-[(2S,3E)-2-phenyl-3-((S)-p-tolylsulfinyl)-3,5-hexadien-2-yl]-4-methylbenzenesulfinamide 
• 66558-07-4 (S)-N-((naphthalen-1-yl)(phenyl)methyl)-4-methylbenzenesulfonamide 
• 66558-07-4 (R)-4-methyl-N-(naphthalen-1-yl(phenyl)methyl)benzenesulfonamide 
• 627503-87-1 N-[(S)-2-methyl-1-phenylpropan-1-yl]-4-methylbenzenesulfonamide 
• 81777-37-9 N-[(R)-2-methyl-1-phenylpropan-1-yl]-4-methylbenzenesulfonamide 
• 66558-06-3 N-[(1S)-1-phenylpropan-1-yl]-4-methylbenzenesulfonamide 
• 64396-66-3 methyl (R)-4-methylbenzenesulfinate 
• 93241-22-6 4-methyl-N-[(1R)-1-phenylpropyl]benzene-1-sulfonamide 
• 6668-27-5 (S)-2-methyl-1-phenylpropane-1-amine 
• 66558-04-1 N-[(1S)-1-phenylethan-1-yl]-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Asymmetric Aldol-Tishchenko Reaction of Sulfinimines

Methods for the preparation of 1,3-amino alcohols and their derivatives containing two stereogenic centers usually involve a two-step installation of the chiral centers. An aldol-Tishchenko reaction of chiral sulfinimines which involves the first reported reduction of a C=N in this type of reaction is described. Two and even three chiral centers can be installed in one synthetic step, affording anti-1,3-amino alcohols in good diastereo- and enantioselectivity.

Asymmetric Induction in the Reduction of Optically Active N-Alkylidenesulphinamides by Metal Hydrides. A New, Efficient Enantioselective Route to Chiral Amines

A series of racemic and optically active N-alkylidenesulphinamides has been prepared and their reduction by metal hydrides studied.The extent of asymmetric synthesis mainly depends on the nature of the reducing species; the best results (up to 92percent of stereoselectivity) are obtained with alkoxy-lithium aluminium hydrides.A new, highly enantioselective synthesis of amines is described.