867006-59-5

Upstream product

• 110-91-8 morpholine 
• 156001-53-5 5-bromo-2-(bromomethyl)benzonitrile 
• 156001-51-3 3-Bromo-6-methyl-benzonitrile 
• 523977-64-2 5-bromo-2-formylbenzonitrile 

Downstream Products

• 1403256-12-1 3'-cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide 
• 867006-60-8 5-(6-benzyloxy-5-ethyl-2-methylpyridin-3-yl)-2-(morpholin-4-yl)methyl-benzonitrile 

Relevant academic research and scientific papers

TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF

The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.

Aryl- or Heteroaryl-Substituted Benzene Compounds

The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP)

The present invention discloses and claims a series of 2,3,5-substituted pyridone derivatives as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5'-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.