86701-21-5

Upstream product

• 14447-41-7 (E)-1-bromo-1,2-diphenylethene 
• 223508-60-9 (p-ethylphenyl)zinc chloride 
• 13027-48-0 rac-1,2-dibromo-1,2-diphenylethane 
• 591-50-4 iodobenzene 
• 40307-11-7 1-ethyl-4-ethynylbenzene 
• 13440-24-9 anti-1,2-dibromo-1,2-diphenylethane 

Relevant academic research and scientific papers

Unexpected and powerful effect of chlorobenzene in direct palladium-catalyzed cascade Sonogashira-hydroarylation reaction

A ubiquitous accelerating effect of chlorobenzene (PhCl) was observed unexpectedly in the Pd-catalyzed cascade Sonogashira-hydroarylation reaction. This new type of carbon-carbon bond forming cross-coupling reaction was efficiently catalysed by Pd2(dba)3 in the presence of a catalytic amount of PhCl, which provides a facile and direct approach to the synthesis of trisubstituted olefins.

Conversion of Stilbene to trisubstituted Olefins

Determination of stereochemistry of bromination-dehydrobromination of both cis and trans-stilbene has been achieved.Coupling of the resulting vinyl bromides with alkyl or aryl groups have been done.The coupling products could serve as intermediates for the synthesis of biologically active tetrasubstituted olefins.