867010-83-1

Upstream product

• 867010-78-4 (R)-2-acetoxy-hexadecanoic acid N-hydroxysuccinimide ester 
• 65-85-0 benzoic acid 
• 95603-89-7 D(R)-α-acetoxypalmitic acid 
• 61490-71-9 (2R)-(+)-1,2-hexadecanediol 
• 867010-80-8 tert-butyl (4S)-4-[(1R,2E,6E)-1-benzoyloxy-7-methylhexadeca-2,6-dienyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 867010-75-1 (R)-1-hydroxy-2-hexadecyl acetate 
• 867010-74-0 (R)-1-tert-butyldimethylsilyloxy-2-hexadecyl acetate 

Relevant academic research and scientific papers

Efficient stereocontrolled synthesis of sphingadienine derivatives

Sphinga-4,8-dienines, principal long-chain bases of glycolipids in plants and fungi, were efficiently synthesized from l-serine. Hydrozirconation of pentadec-5-en-1-ynes followed by ZnBr2-catalyzed addition to Garner's aldehyde afforded protected sphinga-4,8-dienines stereoselectively. The (2S,3R,4E,8E)-9-methyl-sphingadienine derivative was then coupled with 2(R)-acetoxypalmitic acid derivative prepared via asymmetric dihydroxylation to give a protected ceramide, which was converted into the corresponding glucocerebroside in two steps.